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gerAlfer, JoachimBeier, HenningMarkermoleküle endometrialer Funktionen : vergleichende immunhistochemische Lokalisierung bei fertilen und subfertilen Patientinneninfo:eu-repo/classification/ddc/610MedizinFrauSterilitätGebärmutterschleimhautMarkerImmuncytochemieAim of this study was to identify marker molecules for a receptive endometrium. We investigated endometrial biopsies of fertile and subfertile patients. The endometrium of subfertile patients was < 7mm for the whole ovulatory cycle. As animal models and molecular investigations demostrated, three of our selected markers (LIF, Leptin, ß3-Integrin) are leading, when absent or mutated, to infertility. The following markers were investigated by immunohistochemistry: (1.) the cytokines VEGF and LIF, (2.) the hormone leptin and its receptor and (3.) the ß3-integrin. The analyses of these markers during the menstrual cycle of fertile patients showed an expression in the endometrium during the midluteal phase. These observations indicate a significant role for a successful reproduction and we postulate that their expression can be used for the assessment of endometrial receptivity. Subfertile patients were almost negative for these markers. The absence or inadequate expression of the tested molecules might be responsible for subfertility or infertility. The fundamental identity of these markers is their involvement in angiogenesis. Their absence in the endometrium of subfertile patients may contribute to a deficient transformation in this tissue as an indicator for insufficient angiogenesis. The present study enabled us to define the "endometrial factor" on a molecular level, in particular by a deficient angiogenesis as a reason for subfertility.Aachen : Shaker, Fortschritte der Anatomie, Embryologie und Reproduktionsbiologie II, 102 S. : zahlr. Ill., graph. Darst. (2000). = Zugl.: Aachen, Techn. Hochsch., Diss., 2000info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersionShaker2000info:eu-repo/semantics/openAccessDEhttps://publications.rwth-aachen.de/record/53037https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-115216%22StudentsStudent Financial Aid ProvidersTeachersResearchersinfo:eu-repo/semantics/altIdentifier/isbn/3-8265-8002-8info:eu-repo/semantics/altIdentifier/urn/urn:nbn:de:hbz:82-opus-463