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%0 Thesis %A Sadvandi, Gelareh %T Systematic review on effects of experimental orthodontic tooth displacement on brain activation assessed by fMRI %I Rheinisch-Westfälische Technische Hochschule Aachen %V Dissertation %C Aachen %M RWTH-2025-00810 %P 1 Online-Ressource : Illustrationen %D 2025 %Z Veröffentlicht auf dem Publikationsserver der RWTH Aachen University %Z Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2025 %X Orthodontic treatment is often accompanied by discomfort and pain in patients, which are believed to be a result of orthodontic tooth displacement caused by the mechanical forces exerted by the orthodontic appliances on the periodontal tissues. Tooth movement can cause vascular changes, ischemia and release of inflammatory and neurogenic mediators. Using functional magnetic resonance imaging, changes in brain activity can be recorded by measuring blood flow changes. This systematic review aimed to assess the impact of experimental orthodontic tooth displacement on alterations in central nervous system activation. Understanding these activity changes could help in the development of effective methods of pain control. A literature search was conducted using online databases, following PRISMA guidelines and a literature search was conducted through the online databases using the PICO format and pre defined inclusion and exclusion criteria to conduct this work. The initial database search using title and abstract screening resulted in 791 studies. Of these, 234 were duplicates and 547 were deemed irrelevant considering the inclusion and exclusion criteria. Of the ten remaining potential relevant studies, two were excluded during full-text screening. Eight prospective articles were eligible for further analysis. All of the participants in the included studies employed orthodontic separators in short-term experiments to induce tooth displacement during the early stage of orthodontic treatment. The included studies provided evidence of the intricate interplay between orthodontic treatment, pain perception, and brain function.Alterations in brain activation were observed in brain regions, functional connectivity and brain networks. These changes primarily affected regions implicated in nociception (insula, thalamus), emotion (insula, frontal areas), and cognition (frontal areas, cerebellum, default mode network). The results suggest that orthodontic treatment influences beyond the pain matrix and affects other brain regions including the limbic system, which is responsible for memory emotion and behavior. Furthermore, understanding the orthodontically induced brain activation may help in the development of targeted pain management strategies and improve the treatment efficiency. Due to the moderate to serious risk of bias and the heterogeneity of the included studies, further clinical trials on this subject are recommended to enable a meta-analysis. %F PUB:(DE-HGF)11 %9 Dissertation / PhD Thesis %R 10.18154/RWTH-2025-00810 %U https://publications.rwth-aachen.de/record/1002986