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@PHDTHESIS{Sadvandi:1002986,
author = {Sadvandi, Gelareh},
othercontributors = {Michael, Sareh and Modabber, Ali},
title = {{S}ystematic review on effects of experimental orthodontic
tooth displacement on brain activation assessed by f{MRI}},
school = {Rheinisch-Westfälische Technische Hochschule Aachen},
type = {Dissertation},
address = {Aachen},
publisher = {RWTH Aachen University},
reportid = {RWTH-2025-00810},
pages = {1 Online-Ressource : Illustrationen},
year = {2025},
note = {Veröffentlicht auf dem Publikationsserver der RWTH Aachen
University; Dissertation, Rheinisch-Westfälische Technische
Hochschule Aachen, 2025},
abstract = {Orthodontic treatment is often accompanied by discomfort
and pain in patients, which are believed to be a result of
orthodontic tooth displacement caused by the mechanical
forces exerted by the orthodontic appliances on the
periodontal tissues. Tooth movement can cause vascular
changes, ischemia and release of inflammatory and neurogenic
mediators. Using functional magnetic resonance imaging,
changes in brain activity can be recorded by measuring blood
flow changes. This systematic review aimed to assess the
impact of experimental orthodontic tooth displacement on
alterations in central nervous system activation.
Understanding these activity changes could help in the
development of effective methods of pain control. A
literature search was conducted using online databases,
following PRISMA guidelines and a literature search was
conducted through the online databases using the PICO format
and pre defined inclusion and exclusion criteria to conduct
this work. The initial database search using title and
abstract screening resulted in 791 studies. Of these, 234
were duplicates and 547 were deemed irrelevant considering
the inclusion and exclusion criteria. Of the ten remaining
potential relevant studies, two were excluded during
full-text screening. Eight prospective articles were
eligible for further analysis. All of the participants in
the included studies employed orthodontic separators in
short-term experiments to induce tooth displacement during
the early stage of orthodontic treatment. The included
studies provided evidence of the intricate interplay between
orthodontic treatment, pain perception, and brain
function.Alterations in brain activation were observed in
brain regions, functional connectivity and brain networks.
These changes primarily affected regions implicated in
nociception (insula, thalamus), emotion (insula, frontal
areas), and cognition (frontal areas, cerebellum, default
mode network). The results suggest that orthodontic
treatment influences beyond the pain matrix and affects
other brain regions including the limbic system, which is
responsible for memory emotion and behavior. Furthermore,
understanding the orthodontically induced brain activation
may help in the development of targeted pain management
strategies and improve the treatment efficiency. Due to the
moderate to serious risk of bias and the heterogeneity of
the included studies, further clinical trials on this
subject are recommended to enable a meta-analysis.},
cin = {541000-2 ; 937510},
ddc = {610},
cid = {$I:(DE-82)541000-2_20140620$},
typ = {PUB:(DE-HGF)11},
doi = {10.18154/RWTH-2025-00810},
url = {https://publications.rwth-aachen.de/record/1002986},
}
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