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@PHDTHESIS{Wein:1004806,
author = {Wein, Svenja},
othercontributors = {Neuß-Stein, Sabine and Pich, Andrij},
title = {{O}ptimizing fibrin gel architectures and mechanical
properties to advance tissue regeneration and vascular
network formation},
school = {Rheinisch-Westfälische Technische Hochschule Aachen},
type = {Dissertation},
address = {Aachen},
reportid = {RWTH-2025-01634},
pages = {16, 22 Seiten : Illustrationen},
year = {2025},
note = {Dissertation, Rheinisch-Westfälische Technische Hochschule
Aachen, 2025, Kumulative Dissertation},
abstract = {Improving tissue regeneration is a key aspect in the field
of tissue engineering. The focus here is on the development
of advanced scaffold designs to optimize their effectiveness
and functionality. Fibrin hydrogel as a key component
provides an excellent basis due to its biocompatibility and
similarity to the natural extracellular matrix, providing an
ideal environment for cell attachment and growth. By
modifying these fibrin hydrogels with copolymers such as
$PVP12400-co-GMA10mol\%,$ the mechanical properties of the
hydrogels can be controlled, and their structural
characteristics improved. As a result, this scaffold design
can promote angiogenesis, which is essential for creating
larger tissue constructs that extend beyond natural
diffusion limits. The copolymer-modified hydrogels exhibit
an increased storage modulus and improved degradation rates,
which particularly promote angiogenesis. These properties
are crucial for the effective pre-vascularization of
biohybrid implants. Another innovation is the development of
a scaffold design that enables the controlled release of
hepatocyte growth factor (HGF), which plays an important
role in wound healing. This design comprises a multilayered
structure of fibrin hydrogels with integrated HGF, the
design of which has been optimized so that the bioactivity
of HGF is maintained over longer periods of time. These
studies have confirmed that this scaffold maintains the
regenerative capabilities of HGF and supports key cellular
processes required for effective tissue regeneration. The
fibrin hydrogel scaffold was designed to work
synergistically with the body's natural healing mechanisms
to effectively support wound healing. This approach promotes
the recruitment of the body's own mesenchymal stem cells
(MSCs) from their niches and thus supports tissue remodeling
and wound healing directly at the potential implantation
site. The use of fibrin hydrogel as a source material for
both mechanically enhanced hydrogels and scaffolds with
integrated growth factors such as HGF opens new
possibilities for the development of effective therapeutic
strategies in regenerative medicine. These advances improve
the treatment of chronic wounds and complex tissue injuries.
By optimizing scaffold functionality and prolonging the
bioactivity of key growth factors, these materials are
poised to play an important role in tissue repair and
regeneration.},
cin = {528001-2 ; 922910},
ddc = {610},
cid = {$I:(DE-82)528001-2_20140620$},
typ = {PUB:(DE-HGF)11},
url = {https://publications.rwth-aachen.de/record/1004806},
}
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