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TY  - THES
AU  - Schadt, Melina
TI  - Functional surfaces and membranes from supercharged unstructured peptide fusion proteins
PB  - RWTH Aachen University
VL  - Dissertation
CY  - Aachen
M1  - RWTH-2025-04737
SP  - 1 Online-Ressource : Illustrationen
PY  - 2025
N1  - Veröffentlicht auf dem Publikationsserver der RWTH Aachen University
N1  - Dissertation, RWTH Aachen University, 2025
AB  - This thesis investigates a protein-based approach for surface functionalization, utilizing recombinant fusion proteins made of surface-binding peptides (SBPs) and supercharged, unstructured polypeptides (SUPs). SBP-SUP fusion proteins were investigated in three different projects. First, they were used to modify textile surfaces, resulting in increased hydrophilicity, improved moisture management, and showed high wash resistance, particularly on PET textiles. Second, the effect of negatively charged fusion proteins on the adhesion of SUP-based adhesives to polyethylene was examined, and showed an enhanced adhesion correlating with increased surface hydrophilicity. In the third project, SUP-based vesicles formed with charged surfactants were developed and analyzed in terms of size and morphology. The obtained vesicles showed promising biomimetic properties. The SBP-SUP fusion proteins showed to be a modular and genetically tunable platform for surface modification across diverse materials.
LB  - PUB:(DE-HGF)11
DO  - DOI:10.18154/RWTH-2025-04737
UR  - https://publications.rwth-aachen.de/record/1011800
ER  -