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@PHDTHESIS{Knobloch:1012049,
      author       = {Knobloch, Simon},
      othercontributors = {Habel, Ute and Reindl, Vanessa},
      title        = {{E}mpathy in schizophrenia: neural alterations during
                      emotion recognition and affective sharing},
      school       = {Rheinisch-Westfälische Technische Hochschule Aachen},
      type         = {Dissertation},
      address      = {Aachen},
      publisher    = {RWTH Aachen University},
      reportid     = {RWTH-2025-04832},
      pages        = {1 Online-Ressource : Illustrationen},
      year         = {2025},
      note         = {Veröffentlicht auf dem Publikationsserver der RWTH Aachen
                      University; Dissertation, Rheinisch-Westfälische Technische
                      Hochschule Aachen, 2025},
      abstract     = {Introduction: Deficits in emotion recognition and
                      processing are characteristic for patients with
                      schizophrenia [SCZ]. Methods: We targeted both emotion
                      recognition and affective sharing, one in static and one in
                      dynamic facial stimuli, during functional magnetic resonance
                      imaging [fMRI] in 22 SCZ patients and 22 matched healthy
                      controls [HC]. Current symptomatology and cognitive deficits
                      were assessed as potential influencing factors. Results:
                      Behaviorally, patients only showed a prolonged response time
                      in age-discrimination trials. For emotion-processing trials,
                      patients showed a difference in neural response, without an
                      observable behavioral correlate. During emotion and age
                      recognition in static stimuli, a reduced activation of the
                      bilateral anterior cingulate cortex [ACC] and the right
                      anterior insula [AI] emerged. In the affective sharing task,
                      patients showed a reduced activation in the left and right
                      caudate nucleus, right AI and inferior frontal gyrus [IFG],
                      right cerebellum, and left thalamus, key areas of empathy.
                      Discussion: We conclude that patients have deficits in
                      complex visual information processing regardless of
                      emotional content on a behavioral level and that these
                      deficits coincide with aberrant neural activation patterns
                      in emotion processing networks. The right AI as an
                      integrator of these networks plays a key role in these
                      aberrant neural activation patterns and, thus, is a
                      promising candidate area for neurofeedback approaches.},
      cin          = {535500-2 ; 934910},
      ddc          = {610},
      cid          = {$I:(DE-82)535500-2_20140620$},
      pnm          = {GRK 2150 - GRK 2150: Neuronale Grundlagen der Modulation
                      von Aggression und Impulsivität im Rahmen von
                      Psychopathologie (269953372)},
      pid          = {G:(GEPRIS)269953372},
      typ          = {PUB:(DE-HGF)11},
      doi          = {10.18154/RWTH-2025-04832},
      url          = {https://publications.rwth-aachen.de/record/1012049},
}