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@PHDTHESIS{Daverzhofen:1012417,
      author       = {Daverzhofen, Helen Maria},
      othercontributors = {Brandenburg, Lars-Ove and Tauber, Simone},
      title        = {{N}eurogenese nach einer akuten {P}neumokokken-{I}nfektion
                      : {E}influss der {F}ormyl-{P}eptid-{R}ezeptoren und deren
                      {S}ubstrat {A}c2-26},
      school       = {Rheinisch-Westfälische Technische Hochschule Aachen},
      type         = {Dissertation},
      address      = {Aachen},
      reportid     = {RWTH-2025-04986},
      pages        = {VI, 90 Seiten : Illustrationen},
      year         = {2024},
      note         = {Dissertation, Rheinisch-Westfälische Technische Hochschule
                      Aachen, 2024},
      abstract     = {The infection with S. pneumoniae leads to a meningitis
                      infection. This is a potentially fatal disease. Nearly
                      $50\%$ of the survivors suffer after the acute pneumococcus
                      infection from long term complications like cognitive
                      impairment, neurological deficits and hearing loss. In this
                      study we investigate the effect of the bioactive fragment
                      Ac2-26 in correlation with an acute pneumococcus infection.
                      The fragment Ac2-26 is part of the peptide Annexin A1 and is
                      a ligand to the family of formyl peptide receptors (FRP).
                      The focus of this study was the effect of the treatment with
                      Ac2-26 regarding the outcome and the neurogenesis showed
                      with a mouse model. For the long-term complications, we used
                      the Morris Water Maze test (MWM). With this test we study
                      the learning and orientation ability. The rate of
                      neurogenesis we showed with immunohistochemistry. We used
                      the antibodies for tyrosine receptor kinase B (TrkB), a
                      receptor of brain derived neurotrophic factor (BDNF),
                      bromdesoxyuridine (BrdU) and the neuronal nuclear antigen
                      Neuronal nuclei (NeuN), to show the new mature neurons in
                      the hippocampal region of the brain and Synaptophysin as an
                      integral membrane glycoprotein for the presynaptic vesicle.
                      In addition, we used the real-time polymerase chain reaction
                      (qRT-PCR) to measure the expression of the mRNS of
                      Synaptophysin. The results did not show a better performance
                      in the MWM. Further only a little increase of the
                      neurogenesis after the treatment with Ac2-26 could be shown.
                      In addition, we showed a positive effect of the expression
                      of Synaptophysin through the treatment with Ac2-26. Taken
                      together the results show a positive effect of Ac2-26 to the
                      inflammation reaction and the regeneration after the
                      infection. The injection of Ac2-26 increased the number of
                      new neurons and effects the synaptic functions positive. But
                      it must be mentioned that the neurogenesis was stronger
                      after the infection with S. pneumoniae than under the
                      treatment with Ac2-26. So, it has been shown, that the
                      treatment with Ac2-26 after the infection with S. pneumoniae
                      is able to modulate the inflammatory response.},
      cin          = {511001-5 ; 921210},
      ddc          = {610},
      cid          = {$I:(DE-82)511001-5_20140620$},
      typ          = {PUB:(DE-HGF)11},
      url          = {https://publications.rwth-aachen.de/record/1012417},
}