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TY  - THES
AU  - Kaden, Marc-Pascal
TI  - Inflammatorische Reaktionsmechanismen in lymphatischen Geweben nach Polytraumaversorgung im Großtiermodell
PB  - Rheinisch-Westfälische Technische Hochschule Aachen
VL  - Dissertation
CY  - Aachen
M1  - RWTH-2025-05704
SP  - 1 Online-Ressource : Illustrationen
PY  - 2025
N1  - Veröffentlicht auf dem Publikationsserver der RWTH Aachen University
N1  - Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2025
AB  - Traumatic influences on the body cause a variety of inflammatory mechanisms, which are largely understood in the hematologic system. However, the lymphatic system is also of great importance for the development and further transport of reaction equivalents. The processes occurring there are still only partially understood and require further clarification in order to enable a better prognosis and objectification of the severity of inflammation. In this study, individual lymph node stations from the cervical, pulmonary, ileal and abdominal regions are examined for the level of their cytokines FLT3LG, IL-6, IL-10, TLR4 and VEGFc. Prior to this, the test animals were subjected to a bilateral femoral fracture, haemorrhagic shock, liver laceration and lung contusion and placed in a polytraumatized state. This was followed by guideline-compliant treatment with an external fixator or intramedullary nailing with and without simultaneous administration of a complement inhibitor. After euthanasia and collection of the tissue samples, the individual lymph nodes were examined using ELISA tests.  The comparison between the individual therapy groups showed that all previously traumatized pigs showed increased inflammation in their lymph nodes compared to the control group and the trauma groups without CD14/C5 treatment, that the antibody treatment had a suppressive effect on the release of inflammatory proteins and that the lymphatic barrier disorder in the gastrointestinal tract brought them closer to different intervention groups in terms of proinflammation. The influence of various factors on the lymphatic tissue with regard to the lymph node station and the level of the measured cytokine values is discussed. A mesenteric barrier disorder in the area of the abdominal and ileal lymphnodes is critically examined as a possible factor, as are the resulting changes in the pulmonary milieu. Intracerebral processes and the probability of ARDS are discussed in particular for their first lymph node stations in the neck and lung area. Since the experimental setup is a snapshot after 72 hours and there are anatomical differences between the porcine and human species, lymphatic examinations should be supplemented by CSF and blood tests in order to provide a better explanation of lymphatic reaction mechanisms.
LB  - PUB:(DE-HGF)11
DO  - DOI:10.18154/RWTH-2025-05704
UR  - https://publications.rwth-aachen.de/record/1013785
ER  -