h1

% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@PHDTHESIS{Kaden:1013785,
      author       = {Kaden, Marc-Pascal},
      othercontributors = {Eschweiler, Jörg and Hein, Marc},
      title        = {{I}nflammatorische {R}eaktionsmechanismen in lymphatischen
                      {G}eweben nach {P}olytraumaversorgung im {G}roßtiermodell},
      school       = {Rheinisch-Westfälische Technische Hochschule Aachen},
      type         = {Dissertation},
      address      = {Aachen},
      publisher    = {RWTH Aachen University},
      reportid     = {RWTH-2025-05704},
      pages        = {1 Online-Ressource : Illustrationen},
      year         = {2025},
      note         = {Veröffentlicht auf dem Publikationsserver der RWTH Aachen
                      University; Dissertation, Rheinisch-Westfälische Technische
                      Hochschule Aachen, 2025},
      abstract     = {Traumatic influences on the body cause a variety of
                      inflammatory mechanisms, which are largely understood in the
                      hematologic system. However, the lymphatic system is also of
                      great importance for the development and further transport
                      of reaction equivalents. The processes occurring there are
                      still only partially understood and require further
                      clarification in order to enable a better prognosis and
                      objectification of the severity of inflammation. In this
                      study, individual lymph node stations from the cervical,
                      pulmonary, ileal and abdominal regions are examined for the
                      level of their cytokines FLT3LG, IL-6, IL-10, TLR4 and
                      VEGFc. Prior to this, the test animals were subjected to a
                      bilateral femoral fracture, haemorrhagic shock, liver
                      laceration and lung contusion and placed in a
                      polytraumatized state. This was followed by
                      guideline-compliant treatment with an external fixator or
                      intramedullary nailing with and without simultaneous
                      administration of a complement inhibitor. After euthanasia
                      and collection of the tissue samples, the individual lymph
                      nodes were examined using ELISA tests. The comparison
                      between the individual therapy groups showed that all
                      previously traumatized pigs showed increased inflammation in
                      their lymph nodes compared to the control group and the
                      trauma groups without CD14/C5 treatment, that the antibody
                      treatment had a suppressive effect on the release of
                      inflammatory proteins and that the lymphatic barrier
                      disorder in the gastrointestinal tract brought them closer
                      to different intervention groups in terms of
                      proinflammation. The influence of various factors on the
                      lymphatic tissue with regard to the lymph node station and
                      the level of the measured cytokine values is discussed. A
                      mesenteric barrier disorder in the area of the abdominal and
                      ileal lymphnodes is critically examined as a possible
                      factor, as are the resulting changes in the pulmonary
                      milieu. Intracerebral processes and the probability of ARDS
                      are discussed in particular for their first lymph node
                      stations in the neck and lung area. Since the experimental
                      setup is a snapshot after 72 hours and there are anatomical
                      differences between the porcine and human species, lymphatic
                      examinations should be supplemented by CSF and blood tests
                      in order to provide a better explanation of lymphatic
                      reaction mechanisms.},
      cin          = {534000-2 ; 934710},
      ddc          = {610},
      cid          = {$I:(DE-82)534000-2_20140620$},
      typ          = {PUB:(DE-HGF)11},
      doi          = {10.18154/RWTH-2025-05704},
      url          = {https://publications.rwth-aachen.de/record/1013785},
}