h1

TY  - THES
AU  - Vossen, Laura Victoria
TI  - Langzeit-Outcome der endovaskulären Rescue-Therapie bei verzögerten zerebralen Ischämien nach aneurysmatischer Subarachnoidalblutung
PB  - Rheinisch-Westfälische Technische Hochschule Aachen
VL  - Dissertation
CY  - Aachen
M1  - RWTH-2025-05742
SP  - 1 Online-Ressource : Illustrationen
PY  - 2025
N1  - Veröffentlicht auf dem Publikationsserver der RWTH Aachen University
N1  - Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2025
AB  - Compared to other forms, aSAB is a particularly serious variant of stroke. Due to a much younger age of onset and high mortality, it leads to a significant loss of productive life years. Furthermore, the functional outcome of patients can also be negatively affected by the occurrence of DCI. For DCI therapy, currently only the prophylactic application of nimodipine and iHTN are recommended in the guidelines. The evidence for the use of ERT is currently the subject of research and is not yet recommended at this time. The present study is based on one of the largest available IAN cohorts, dealing with the long-term clinical outcome after ERT in DCI.Within the study, intra-arterial spasmolysis induced by nimodipine was associated with a low rate of specific treatment-related complications, especially with continuous IAN use. Despite being a cohort of severely affected aSAB patients, nearly half of all patients treated with IAN were able to regain independent living within one year. As a comparison with a control cohort could not be realised, careful selection of patients and precise indication prior to IAN application is still mandatory. The outcome was significantly negatively influenced by the severity of the aSAB and the occurrence of DCI - age also played a significant role. In the future, the above results should be reviewed in prospective, randomised studies to confirm the superiority of ERT in the DCI treatment algorithm compared to prophylactic nimodipine therapy in combination with iHTN in terms of effectiveness and therapeutic safety. Updated DCI treatment recommendations could then improve the clinical outcome of affected patients in the long term.
LB  - PUB:(DE-HGF)11
DO  - DOI:10.18154/RWTH-2025-05742
UR  - https://publications.rwth-aachen.de/record/1013856
ER  -