Gast ::
TY - THES AU - Fink, Nicolas Heinrich TI - IL-2 differentially activates the human mast cell leukemia cell lines HMC-1.1 and HMC-1.2 PB - Rheinisch-Westfälische Technische Hochschule Aachen VL - Dissertation CY - Aachen M1 - RWTH-2025-06630 SP - VIII, 65 Seiten : Illustrationen PY - 2025 N1 - Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2025 AB - Systemic mastocytosis (SM) is a heterogeneous mast cell disease that is divided into 3 subtypes. While patients with an indolent SM mainly suffer from the release of proinflammatory mediators, the aggressive SM is characterized by mast cell infiltration into the bone marrow and organs. The most aggressive variant of SM is mast cell leukemia (MCL), characterized by the accumulation of mast cells in the bloodstream. This is associated with a very short life expectancy of around three months after diagnosis. The majority (about 90 LB - PUB:(DE-HGF)11 UR - https://publications.rwth-aachen.de/record/1015901 ER -