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@PHDTHESIS{Cheng:1018423,
      author       = {Cheng, Jianan},
      othercontributors = {Rink, Lothar and Wessels, Inga},
      title        = {{Z}inc supplementation reduces the formation of neutrophil
                      extracellular traps by decreasing the expression of peptidyl
                      arginine deiminase 4},
      school       = {Rheinisch-Westfälische Technische Hochschule Aachen},
      type         = {Dissertation},
      address      = {Aachen},
      reportid     = {RWTH-2025-07841},
      pages        = {11 Blätter : Illustrationen},
      year         = {2025},
      note         = {Dissertation, Rheinisch-Westfälische Technische Hochschule
                      Aachen, 2025},
      abstract     = {Neutrophils play a decisive role during the immediate
                      defense against infections. However, their deregulation, as
                      observed during rheumatoid arthritis, can also cause tissue
                      damage. Previous studies indicate that zinc supplementation
                      may alter certain neutrophil functions. However, the precise
                      underlying mechanisms as well as possible effects of zinc
                      deficiency remain incompletely understood. The objective of
                      this study was to investigate the effects of zinc
                      homeostasis on formation of neutrophil extracellular traps
                      (NETs) and other fundamental neutrophil functions. We used
                      interleukin (IL)-17 and tumor necrosis factor (TNF)-α to
                      simulate the inflammatory environment observed in autoimmune
                      diseases. Subsequently, we analyzed the impact of different
                      extracellular zinc concentrations on the release of NETs,
                      using a fluorescence plate reader, as well as on the
                      expression of peptidylarginine deiminase 4 (PAD4), S100A8/A9
                      and certain cytokines by PCR and western blot. Our research
                      shows that zinc supplementation significantly reduces NETs
                      formation, which may involve downregulation PAD4 expression.
                      Additionally, zinc supplementation resulted in increasing
                      the expression of interleukin-1 receptor antagonist (IL-1RA)
                      and IL-8. The results demonstrate that changes in
                      extracellular zinc availability can influence the functions
                      of neutrophils. Therefore, maintaining an appropriate zinc
                      level is crucial for preserving the function of innate
                      immunity.},
      cin          = {525501-2 ; 924820},
      ddc          = {610},
      cid          = {$I:(DE-82)525501-2_20140620$},
      typ          = {PUB:(DE-HGF)11},
      url          = {https://publications.rwth-aachen.de/record/1018423},
}