h1

TY  - THES
AU  - Hangen Rodriguez, Sara Gabriela
TI  - Korrelation von Fetuin-B mit der systemischen Immunmodulation in Kinderwunsch-Patientinnen
PB  - Rheinisch-Westfälische Technische Hochschule Aachen
VL  - Dissertation
CY  - Aachen
M1  - RWTH-2025-08037
SP  - 1 Online-Ressource : Illustrationen
PY  - 2025
N1  - Veröffentlicht auf dem Publikationsserver der RWTH Aachen University
N1  - Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2025
AB  - In Germany, nearly one in ten couples aged 25 to 45 who wish to have children remain childless. Infertility causes can lie with either the man or the woman. There is no clear definition yet on how to predict success for women undergoing Assisted Reproductive Technology (ART) -treatment. Evidence suggests that metabolic disorders and associated inflammatory conditions may negatively impact egg quality in ART, but research is insufficient. Fetuin-B, a liver protein, plays a role in sperm binding to the zona pellucida in mice and is discussed as an acute-phase protein in metabolic-inflammatory contexts. This study aimed to explore the relationship between metabolic imbalances, systemic inflammation, and egg quality in ART, focusing on whether markers like Fetuin-B could predict treatment success. The study included 56 women treated for infertility at the University Hospital Aachen. Blood samples were taken twice: two days before ovulation induction (t1) and on the day of embryo transfer (t2). The gene expression of inflammasomes (NLRP2, NLRP3, NLRC4, AIM2) was analyzed via real-time PCR, and serum Fetuin-B levels were measured with ELISA. Additional inflammatory and metabolic parameters were measured in the hospital’s central lab. Egg maturation and fertilization rates were used as fertility indicators. The results showed no correlation between Fetuin-B levels and egg maturation or fertilization rates. However, the total number of eggs retrieved was significantly correlated with Fetuin-B at both time points [t1: p = 0.02, t2: p = 0.0008]. Women with an egg maturation of 100
LB  - PUB:(DE-HGF)11
DO  - DOI:10.18154/RWTH-2025-08037
UR  - https://publications.rwth-aachen.de/record/1018894
ER  -