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%0 Thesis %A Hansen, Nadja %T Entwicklung eines 3D-biogedruckten Blutgefäßersatzes zur Untersuchung des zellulären Verhaltens in In-vitro-Gewebemodellen unter dynamischer Kultivierung %I Rheinisch-Westfälische Technische Hochschule Aachen %V Dissertation %C Aachen %M RWTH-2025-08995 %P 1 Online-Ressource : Illustrationen %D 2025 %Z Veröffentlicht auf dem Publikationsserver der RWTH Aachen University 2026 %Z Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2025 %X The present work describes the development of a novel 3D-bioprinted in vitro model of a blood vessel to provide new insights into the mechanisms of tissue angiogenesis and to test new drug substances. A bioreactor made of PEEK was developed, which enables direct imaging and perfusion. Furthermore, different collagen- and fibrin-based hydrogels were tailored to the different cell types, compared with each other and the cell-ECM interactions were studied. The results show the benefit of pure 2.5 %F PUB:(DE-HGF)11 %9 Dissertation / PhD Thesis %R 10.18154/RWTH-2025-08995 %U https://publications.rwth-aachen.de/record/1020439