h1

TY  - THES
AU  - Negm, Shams
TI  - Resveratrol modulates phosphorylation of ERK and AKT in murine cementoblasts during in vitro orthodontic compression
PB  - Rheinisch-Westfälische Technische Hochschule Aachen
VL  - Dissertation
CY  - Aachen
M1  - RWTH-2026-00101
SP  - 1 Online-Ressource : Illustrationen
PY  - 2025
N1  - Veröffentlicht auf dem Publikationsserver der RWTH Aachen University 2026
N1  - Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2025
AB  - Orthodontic tooth movement occurs in the setting of a sterile inflammatory reaction. A dysregulation of this process can lead to a pathologically increased osteoclast activity in radicular proximity and thus to unwanted root resorption. It has already been described in the literature that root cementum cells can modulate such recruitment of osteoclast precursors and cementum repair. Subject of this dissertation is to investigate a potential biomodulator that could influence root cementum cells and further inhibit apical root resorption – the most common side effect of orthodontics. In this context, resveratrol is of interest: it is a plant polyphenol that is often found in vegetables, fruits, flowers, grains, peanuts, tea and red wine and is known for its anti-inflammatory and pro-regenerative properties. The effect of resveratrol on murine cementoblasts (OCCM-30 cells) – which were mechanically stimulated to simulate the orthodontic pressure zone – was examined, in terms of cell viability, mRNA expression and protein levels of pro-inflammatory cytokines, as well as the modulation of central kinases. The results showed a time- and dose-dependent viability-promoting effect of resveratrol on cementoblasts and a significant reduction in the upregulation of pERK and pAKT, which are upstream regulators of key metabolic signaling pathways. Furthermore, it was observed for the first time that cementoblasts respond to compression with increased activation of STAT3 and elevated translocation of NF-κB p65 into the nucleus. This provides new insights into the physiology of cementoblasts during tooth movement. Based on the already known anti-inflammatory effect of resveratrol on periodontal fibroblasts, it could prove to be a useful drug to modulate the periodontal response to mechanical stimulation; without negatively affecting cementoblasts.
LB  - PUB:(DE-HGF)11
DO  - DOI:10.18154/RWTH-2026-00101
UR  - https://publications.rwth-aachen.de/record/1024488
ER  -