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@PHDTHESIS{Mork:1024915,
author = {Mork, Matthias},
othercontributors = {De Laporte, Laura and Herrmann, Andreas},
title = {{M}icrofluidic fabrication of tailored microgels for tissue
engineering applications},
school = {Rheinisch-Westfälische Technische Hochschule Aachen},
type = {Dissertation},
address = {Aachen},
reportid = {RWTH-2026-00404},
pages = {189 Seiten : Illustrationen},
year = {2025},
note = {Dissertation, Rheinisch-Westfälische Technische Hochschule
Aachen, 2025},
abstract = {Tissue engineering has emerged as a relevant scientific
field that is capable of improving the quality of human life
of current and future generations by selectively targeting
and providing insights into current medical or biomedical
challenges. One particular challenge is to develop platforms
that are able to better understand, regenerate, and replace
human tissues. In this aspect, microgels are promising
materials, featuring various attractive properties.
Droplet-based microfluidics presents a promising continuous
production method for fabricating microgels featuring
desired properties and characteristics for biomedical or
tissue engineering applications. In this thesis, the
development of different microfluidic platforms and their
implementation is demonstrated, aiming at fabricating a
variety of microgels that can solve different tasks in
tissue engineering applications. Conceptually, the efforts
were directed towards different aspects regarding the
microfluidic production and application of the produced
materials, which include: production scalability of
spherical and rod-shaped microgels, introducing
functionality into microgels with special attention on
forming three-dimensional (3D) microgel-cell constructs, and
developing a platform for locally releasing specific
biomolecules directly from microgels. The development of
parallelized step emulsification microfluidic devices for
producing spherical microgels is addressed. Moreover, the
development of a microfluidic platform that combines step
emulsification with droplet confinement and crosslinking in
parallelized microchannels for fabricating rod-shaped
microgels in parallel is presented. Further, it is outlined
how the produced microgels can be implemented as substrates
in generating 3D cell-material assemblies, with special
focus on achieving a platform to reproducibly create 3D
induced pluripotent stem cell (iPSC) microgel constructs in
sizes ranging from the micro- to millimeter scale, based on
spherical polyethylene glycol (PEG)-based microgels. In
addition to providing substrates, droplet microfluidics can
give rise to microcapsules, capable of encapsulating and
releasing biomolecules. A platform was developed to generate
porous PEG-based microcapsules from double emulsion
droplets, featuring different pore sizes, creating promising
carriers for a diffusion-based delivery of biomolecules,
provided that the release properties are system specifically
tuned.},
cin = {154610 / 150000},
ddc = {540},
cid = {$I:(DE-82)154610_20140620$ / $I:(DE-82)150000_20140620$},
typ = {PUB:(DE-HGF)11},
url = {https://publications.rwth-aachen.de/record/1024915},
}
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