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@PHDTHESIS{Amels:1028721,
author = {Amels, Anna Maria},
othercontributors = {Beier, Justus and Eickhoff, Roman},
title = {{U}ntersuchungen zum {E}influss der
{E}rdalkalimetallionenkonzentration auf die osteogene und
myogene {D}ifferenzierung von humanen {F}ettstammzellen : am
{B}eispiel von {C}a²⁺ und {M}g²⁺},
school = {Rheinisch-Westfälische Technische Hochschule Aachen},
type = {Dissertation},
address = {Aachen},
publisher = {RWTH Aachen University},
reportid = {RWTH-2026-01837},
pages = {1 Online-Ressource : Illustrationen},
year = {2026},
note = {Veröffentlicht auf dem Publikationsserver der RWTH Aachen
University; Dissertation, Rheinisch-Westfälische Technische
Hochschule Aachen, 2026},
abstract = {Complex culture media are commonly used to direct the
differentiation of mesenchymal stem cells in vitro. However,
their composition presents a major challenge for clinical
application, as many components carry potential in vivo
risks. A key goal in tissue engineering is therefore to
reduce potentially hazardous supplements while maintaining
effective differentiation. This dissertation investigated
the effects of calcium and magnesium ions on the osteogenic
and myogenic differentiation of ASCs and HSKs. Under the
experimental conditions applied in this work, osteogenesis
could not be induced by these ions alone. Nevertheless,
early osteogenic phases were enhanced, and cell
proliferation increased, suggesting a synergistic
interaction with the established differentiation medium.
There were also indications of a pro-myogenic effect of the
ions, which require further quantitative validation.
Overall, the results confirm the biocompatibility of the
applied compounds and highlight their potential for tissue
engineering applications. Under the conditions used in this
study, calcium and magnesium ions supported differentiation
processes but could not fully replace established
supplements.},
cin = {533530-2 ; 937310},
ddc = {610},
cid = {$I:(DE-82)533530-2_20140620$},
typ = {PUB:(DE-HGF)11},
doi = {10.18154/RWTH-2026-01837},
url = {https://publications.rwth-aachen.de/record/1028721},
}
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