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TY  - THES
AU  - Arrubla, Jorge
TI  - Combined EEG and fMRI for the investigation of loudness dependence of auditory evoked potentials (LDAEP)
PB  - Aachen, Techn. Hochsch.
VL  - Dissertation
CY  - Aachen
M1  - RWTH-2015-04270
PY  - 2015
N1  - Veröffentlicht auf dem Publikationsserver der RWTH Aachen University 2016
N1  - Aachen, Techn. Hochsch., Diss., 2015
AB  - Introduction: Simultaneous recording of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) provides high spatial and temporal resolution. In this study EEG and fMRI were combined to investigate the structures involved in the processing of rising sound pressure levels. Methods:  EEG data were recorded simultaneously with fMRI from 16 healthy volunteers using MR compatible devices at 3 T. Tones with different pressure levels were delivered to the volunteers and the evoked N1/P2 amplitudes were included as covariates into the fMRI data analysis in order to compare the brain responses with high and low intensity tones. Additionally, analysis of variance (ANOVA) and region-of-interest (ROI) analysis were performed. Results: The integration of the ERP parameters into the fMRI analysis showed an extended map of areas with covariance of the N1/P2 amplitudes and the BOLD signal related to the auditory stimuli. The ANOVA and ROI analyses also revealed additional brain areas apart from  the primary auditory cortex (PAC) which were active with the auditory stimulation. Discussion: The PAC and the insula play an important role in the processing of rising sound pressure levels. Additional activations of the anterior cingulate cortex, the opercular cortices and the orbito-frontal cortex were induced by the high intensity tones. A strong response of the visual cortex was also found with the high intensity tones, suggesting the presence of cross-modal effects.
LB  - PUB:(DE-HGF)11
UR  - https://publications.rwth-aachen.de/record/481627
ER  -