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@PHDTHESIS{Arrubla:481627,
      author       = {Arrubla, Jorge},
      othercontributors = {Shah, Nadim Joni and Wiesmann, Martin},
      title        = {{C}ombined {EEG} and f{MRI} for the investigation of
                      loudness dependence of auditory evoked potentials ({LDAEP})},
      school       = {Aachen, Techn. Hochsch.},
      type         = {Dissertation},
      address      = {Aachen},
      reportid     = {RWTH-2015-04270},
      year         = {2015},
      note         = {Veröffentlicht auf dem Publikationsserver der RWTH Aachen
                      University 2016; Aachen, Techn. Hochsch., Diss., 2015},
      abstract     = {Introduction: Simultaneous recording of
                      electroencephalography (EEG) and functional magnetic
                      resonance imaging (fMRI) provides high spatial and temporal
                      resolution. In this study EEG and fMRI were combined to
                      investigate the structures involved in the processing of
                      rising sound pressure levels. Methods: EEG data were
                      recorded simultaneously with fMRI from 16 healthy volunteers
                      using MR compatible devices at 3 T. Tones with different
                      pressure levels were delivered to the volunteers and the
                      evoked N1/P2 amplitudes were included as covariates into the
                      fMRI data analysis in order to compare the brain responses
                      with high and low intensity tones. Additionally, analysis of
                      variance (ANOVA) and region-of-interest (ROI) analysis were
                      performed. Results: The integration of the ERP parameters
                      into the fMRI analysis showed an extended map of areas with
                      covariance of the N1/P2 amplitudes and the BOLD signal
                      related to the auditory stimuli. The ANOVA and ROI analyses
                      also revealed additional brain areas apart from the primary
                      auditory cortex (PAC) which were active with the auditory
                      stimulation. Discussion: The PAC and the insula play an
                      important role in the processing of rising sound pressure
                      levels. Additional activations of the anterior cingulate
                      cortex, the opercular cortices and the orbito-frontal cortex
                      were induced by the high intensity tones. A strong response
                      of the visual cortex was also found with the high intensity
                      tones, suggesting the presence of cross-modal effects.},
      cin          = {535000-5},
      ddc          = {610},
      cid          = {$I:(DE-82)535000-5_20140620$},
      typ          = {PUB:(DE-HGF)11},
      urn          = {urn:nbn:de:hbz:82-rwth-2015-042707},
      url          = {https://publications.rwth-aachen.de/record/481627},
}