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@PHDTHESIS{Dmer:51414,
      author       = {Dömer, Henning},
      othercontributors = {Krombach, Gabriele},
      title        = {{V}ergleich zweier {MRT}-{K}ontrastmittel mit
                      unterschiedlicher {T}1-{R}elaxivität zur
                      {G}efäßdarstellung bei {P}atienten mit abdominellen
                      {A}ortenaneurysmen},
      address      = {Aachen},
      publisher    = {Publikationsserver der RWTH Aachen University},
      reportid     = {RWTH-CONV-113706},
      pages        = {121 S. : Ill., graph. Darst.},
      year         = {2009},
      note         = {Aachen, Techn. Hochsch., Diss., 2009},
      abstract     = {The aim of this tripartite work is the comparison of
                      different paramagnetic contrast agents in the examination of
                      the infrarenal arterial vascular tree in magnetic resonance
                      imaging (MRI) at 1.5 T in a group of patients with
                      infrarenal aortic aneurysms. The two gadolinium-based
                      contrast agents used are Gadopentat dimeglumine or Gd-DTPA
                      (Magnevist®, Schering, Germany) and Gadobenate dimeglumine
                      or Gd-BOPTA (MultiHance®, Bracco, Italy). They differ
                      through their effect on the T1-relaxation of blood.
                      Gadobenate dimeglumine shows a significantly higher
                      relaxivity R in human plasma at 39°C and 20Mhz of R1 =
                      9.7mM-1s-1, in contrast to R1 = 4.9mM-1s-1 for Gadopentat
                      dimeglumine. The findings of the examinations with the
                      different contrast agents were compared with the current
                      standard procedures in angiography, digital subtraction
                      angiography (DSA) and computed tomography (CT). The findings
                      have been diagnosed by 3 radiologists and have been compared
                      regarding the quality of imaging and the validity of
                      findings. In a total 54-patient group this work demonstrates
                      significant advantages in terms of image quality when using
                      the contrast agent of higher T1-relaxivity by
                      inter-individual comparison. Among its use equivalent
                      results in the quality of images compared to DSA for almost
                      the entire infrarenal arterial vascular system are shown.
                      The quality of images for magnetic resonance imaging using
                      Gd-BOPTA is superior to those using Gd-DTPA in almost all
                      examined vessels. The correspondence of findings for MRI and
                      DSA as the reference method shows a higher validity by using
                      Gd-BOPTA. Contrary to expectations no improvement in
                      objectively measurable parameters of image quality using
                      contrast agents in MRI compared to native MRI images can be
                      pointed out in the present study. In planning the treatment
                      of infrarenal abdominal aortic aneurysms imaging plays a
                      crucial role. Currently computed tomography is the method of
                      choice. In this work findings and measurements using
                      contrast-enhanced MRI and CT were compared intraindividual.
                      The quality of images is on a par for MRI and CT. All
                      examined findings necessary for treatment can be shown
                      correctly in MRI. In summary the present work shows an
                      improved imaging quality and increased validity of findings
                      in MRI compared with the current standard diagnostics DSA
                      and CT by using contrast agents of higher T1 relaxivity.},
      keywords     = {Kontrastmittel (SWD) / Aortenaneurysma (SWD) / Magnetische
                      Kernresonanz (SWD) / NMR-Tomographie (SWD) / Gadolinium
                      (SWD) / Spin-Gitter-Relaxation (SWD)},
      cin          = {532010-2},
      ddc          = {610},
      cid          = {$I:(DE-82)532010-2_20140620$},
      typ          = {PUB:(DE-HGF)11},
      urn          = {urn:nbn:de:hbz:82-opus-29351},
      url          = {https://publications.rwth-aachen.de/record/51414},
}