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@PHDTHESIS{Jansen:567789,
      author       = {Jansen, Philipp},
      othercontributors = {Hermanns-Sachweh, Benita and Rath, Björn},
      title        = {{E}ndoglin ({CD}105) expression differentiates between
                      aseptic loosening and periprosthetic joint infection after
                      total joint arthroplasty},
      school       = {RWTH Aachen},
      type         = {Dissertation},
      address      = {Aachen},
      reportid     = {RWTH-2016-00974},
      pages        = {1 Online-Ressource (8 Seiten, 3 ungezählte Seiten) :
                      Illustrationen, Diagramme},
      year         = {2016},
      note         = {Die Dissertation wurde zuvor 2014 als Aufsatz in der
                      Zeitschrift "SpringerPlus" (3:561) veröffentlicht. - Auch
                      veröffentlicht auf dem Publikationsserver der RWTH Aachen
                      University 2016; Dissertation, RWTH Aachen, 2016},
      abstract     = {The differentiation between aseptic loosening and
                      periprosthetic joint infection (PJI) after total joint
                      arthroplastyis essential for successful therapy. A better
                      understanding of pathogenesis of aseptic loosening and PJI
                      may helpto prevent or treat these complications. Previous
                      investigations revealed an increased vascularization in
                      theperiprosthetic membrane in cases of PJI via PET signals.
                      Based on these findings our hypothesis was that PJI
                      isassociated with an increased neovascularization in the
                      periprosthetic membrane.Tissue samples from periprosthetic
                      membranes of the bone-implant interface were investigated
                      histologically forinflammation, wear particles,
                      vascularization and fibrosis. To identify vascular
                      structures antibodies against CD 31,CD 34, factor VIII and
                      CD 105 (endoglin) were applied for immunohistochemical
                      investigations. According to aconsensus classification of
                      Morawietz the tissue samples were divided into four types:
                      type I (wear particle inducedtype, n = 11), type II
                      (infectious type, n = 7), type III (combined type, n = 7)
                      and type IV (indeterminate type, n = 7).Patients with PJI
                      (type II) showed a pronounced infiltration of neutrophil
                      granulocytes in the periprostheticmembrane and an enhanced
                      neovascularization indicated by positive immunoreaction with
                      antibodies against CD105 (endoglin). Tissue samples
                      classified as type I, type III and type IV showed
                      significantly less immune reaction forCD 105.In cases of
                      aseptic loosening and PJI vascularization is found in
                      different expression in periprosthetic membranes.However, in
                      aseptic loosening, there is nearly no neovascularization
                      with CD 105-positive immune reaction.Therefore, endoglin (CD
                      105) expression allows for differentiation between aseptic
                      loosening and PJI.},
      cin          = {528001-2},
      ddc          = {610},
      cid          = {$I:(DE-82)528001-2_20140620$},
      typ          = {PUB:(DE-HGF)11},
      urn          = {urn:nbn:de:hbz:82-rwth-2016-009749},
      UT           = {WOS:000359102500003},
      pubmed       = {pmid:26034672},
      doi          = {10.1186/2193-1801-3-561},
      url          = {https://publications.rwth-aachen.de/record/567789},
}