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@PHDTHESIS{Wilop:57131,
      author       = {Wilop, Stefan},
      othercontributors = {Osieka, Rainhardt},
      title        = {{H}ochdosis-{C}hemotherapie mit anschließender autologer
                      {S}tammzelltransplantation},
      address      = {Aachen},
      publisher    = {Publikationsserver der RWTH Aachen University},
      reportid     = {RWTH-CONV-119199},
      pages        = {III, 102 S. : graph. Darst.},
      year         = {2002},
      note         = {Aachen, Techn. Hochsch., Diss., 2002},
      abstract     = {In the years 1992 to 1998 a number of 59 patients in the
                      department of haematology-oncology of the
                      university-hospital of the RWTH-Aachen have been treated
                      with high-dose chemotherapy with following autologous stem
                      cell transplantation (PBSCT). The high-dose chemotherapy
                      with autologous stem cell transplantation is a treatment
                      superior to the conventional chemotherapy in a set of tumor
                      diseases. The side-effects of a chemotherapy on the
                      hematopoeisis can be overcome by the autologous stem cell
                      transplantation, which otherwise often represent the
                      limiting factor. A complete remission can be achieved by the
                      possible increase of the dose intensity, at the same time
                      can the duration of the remission be extended and also
                      higher healing rates with certain tumor diseases be achieved
                      at a larger number of patients. The PBSCT is surely feasible
                      in centers with appropriate experience and machine as well
                      as personnel equipment. As a possibility of treatment the
                      PBSCT is accepted by most patients and also in the review in
                      the very most cases positively judged. A female patient
                      developed CMV-pneumonia in the consequence of the high-dose
                      therapy and deceased at day 50 after transplantation
                      according to a multi-organ failure. At two patients no
                      sufficient reconstitution of haematopoiesis took place after
                      the transplantation, so that a second stem-cell return took
                      place, which led to a full haematological reconstitution. On
                      30.06.2001 still 23 patients were alive and in regular
                      follow-up, 10 of them free of relapse since the
                      transplantation. In the deceased patients the occurrence of
                      a relapse of the malignant disease was the main cause of
                      death.},
      cin          = {510000-1},
      ddc          = {610},
      cid          = {$I:(DE-82)510000-1_20140620$},
      typ          = {PUB:(DE-HGF)11},
      urn          = {urn:nbn:de:hbz:82-opus-4135},
      url          = {https://publications.rwth-aachen.de/record/57131},
}