32 Koch, Antje Mann, Helmut 510000-1 Publikationsserver der RWTH Aachen University Aachen German 83 S. : Ill., graph. Darst. A serious late effect in the dialsysis treatment is the dialysis associated amyloidosis as a result of accumulation of beta2-M in the serum. Aim of this study was to examine if the beta2-M concentration in blood can be reduced by dialysator-membranes with different permeability and adsorption capacity. For this purpose the following experiments have been carried out: 1. Determination of beta2-M-Clearance during dialysis with cuprophane- and PMMA-membranes. 2. Reduction of beta2-M-concentration in 9 different high-flux- and low-flux-membranes during a dialysis treatment. 3. Observation of beta2-M-concentration during one year of dialysis treatment using 4 different membrane-types at 10 patients each. The experiments show that neither the low-flux-membrane cuprophane nor the low-flux-membrane polysulfone are able to remove beta2-M from the serum of patients. Synthetic high-flux-membranes like polysulfone, polyamid and polymethylmethacrylat (PMMA) however are able to reduce the beta2-M-level during dialysis but without reaching normal results. Among these the PMMA-membrane possibly has the best effects because of its adsorptive capacity. This is demonstrated best in the long-term treatment. With this membrane a clearance of ca. 39ml/min can be reached. Although there is an elimination by synthetic membranes the predialytic concentration of beta2-M in blood is only little lower compared with non-eliminating membranes. Non of the examined membranes is able to normalize the concentration of beta2-M in serum. Because of the small number of cases and the short time of observation it is not possible to give evidence if by a minimal improvement of the elimination of beta2-M by synthetic high-flux-membranes the genesis of dialysis-associated amyloidosis is slowed down or prevented. Aachen, Techn. Hochsch., Diss., 2003 ; PUB:(DE-HGF)11, ; 2, ; Dissertation / PhD Thesis 2003 RWTH-CONV-121142 2003 https://publications.rwth-aachen.de/record/59347