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@PHDTHESIS{Schlter:59548,
      author       = {Schlüter, Michael},
      othercontributors = {Mokwa, Wilfried},
      title        = {{M}ikrofluidische {S}trukturen für biochemische
                      {A}nalysen},
      address      = {Aachen},
      publisher    = {Publikationsserver der RWTH Aachen University},
      reportid     = {RWTH-CONV-121326},
      pages        = {128 S. : Ill., graph. Darst.},
      year         = {2004},
      note         = {Aachen, Techn. Hochsch., Diss., 2004},
      abstract     = {The immunoassay is an important serological detection
                      method for biochemical active materials (antigens /
                      anti-bodies). By designing appropriate micro fluidic
                      structures to perform the classic process steps of an
                      immunoassay it can be integrated on a microfluidic chip. The
                      reagents are transported through a micro fluidic reaction
                      chamber where they perform the biochemical reactions. These
                      reagents are stored in the micro-fluidic channels on the
                      chip. The suitability of adhesive foils as low priced and
                      simple seals of the microfluid channels is shown by
                      performing immunoassays in micro-fluid cuvette structures.
                      Signal detection can be performed by fluorescence and by
                      chemoluminescence with sufficient accuracy for, e.g. the
                      diagnosis of a cardiac infarct. A micro pump with two
                      dimensional valve structures without moving parts was
                      developed for the liquid-handling on the micro-fluidic chip.
                      This pump can be manufactured by photolithographic
                      techniques for prototyping as well as by mass production
                      processes, like hot embossing and injection moulding.
                      Integration of this micro pump into fluidic chip structures
                      manufactured from SU-8 photoresist shows the suitability of
                      this pump for the production of micro-fluid analysis
                      systems. A computer control was developed, which can operate
                      the complete process cycle for a micro-fluidic Immunoassay.
                      The performance of the micro pump, and the reaction chamber
                      were optimized by computer simulations. The channel crossing
                      where the different reagents enter the reaction chamber was
                      also improved by computational fluid dynamics (cfd). The
                      performance of a myoglobin immunoassay in a completely
                      integrated fluidic chip manufactured from PMMA shows the
                      capability of detection of a myoglobin concentration of less
                      than 100 ng/m. The measurement of these myoglobin
                      concentrations can be used for the detection of cardiac
                      infarcts from human blood samples.},
      cin          = {600000},
      ddc          = {570},
      cid          = {$I:(DE-82)600000_20140620$},
      typ          = {PUB:(DE-HGF)11},
      urn          = {urn:nbn:de:hbz:82-opus-8936},
      url          = {https://publications.rwth-aachen.de/record/59548},
}