h1

TY  - THES
AU  - Giesen, Kirsten
TI  - Identifikation und Charakterisierung von Suszeptibilitätsloci für Adipositas und Hypercholesterinämie in der NZO-Maus
CY  - Aachen
PB  - Publikationsserver der RWTH Aachen University
M1  - RWTH-CONV-121412
SP  - 60 S. : Ill., graph. Darst.
PY  - 2004
N1  - Aachen, Techn. Hochsch., Diss., 2004
AB  - A backcross model of the obese, hyperglycemic New Zealand obese (NZO) mouse with the lean SJL strain was established in order to locate genes responsible for obesity and the associated syndrome of insulin resistance, hyperglycemia and dyslipidemia, and to compare the effects under a standard and a high fat diet. The pattern of symptoms presented by the NZO mouse closely resembles the human metabolic syndrome, suggesting a common pathophysiology. A genome wide scan revealed a susceptibility locus for obesity and hyperinsulinemia (Nob1) on mouse chromosome 5 in the vicinity of the markers D5Mit392 and D5Mit302. Nob1 contributed to higher body weight and insulin resistance (LOD-score for BMI > 11). The effect of Nob1 on body weight and insulin resistance was enhanced by a high fat diet. Although a sole effect of the leptin receptor variant of the NZO mouse (LeprA720T/T1044I) on the development of obesity could not be observed, LeprNZO significantly contributed to higher body weight in combination with Nob1. Furthermore, Nob1 accelerated and aggravated the development of diabetes in carriers of the diabetogenic Nidd/SJL allele. The synergistic effects of the susceptibility locus for hyperglycemia and islet cell failure Nidd/SJL, and the obesity locus Nob1 accounted for 90
LB  - PUB:(DE-HGF)11
UR  - https://publications.rwth-aachen.de/record/59646
ER  -