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@PHDTHESIS{vonBassewitz:60613,
      author       = {von Bassewitz, Julia},
      othercontributors = {Rath, Werner},
      title        = {{T}hrombophilie als mögliche {U}rsache für vorzeitige
                      {P}lazentalösung},
      address      = {Aachen},
      publisher    = {Publikationsserver der RWTH Aachen University},
      reportid     = {RWTH-CONV-122315},
      pages        = {IX, 117 S. : graph. Darst.},
      year         = {2006},
      note         = {Aachen, Techn. Hochsch., Diss., 2006},
      abstract     = {Subject of the study was the analysis of a possible
                      correlation between placental abruption and thrombophilia.
                      56 women of Caucasian origin in the age-bracket of 20 to 41
                      years participated in the study. The 56 women were treated
                      in the gynaecological department of the RWTH Aachen between
                      1994 and 2001 because of premature placental abruption.
                      Excluded from the study were women with illnesses that
                      changed the diagnosis of thrombophilia or who were pregnant.
                      Under consideration of all factors for thrombophilia 45
                      women $(80.36\%)$ showed abnormalities in screening, 20
                      women $(35.71\%)$ had combined defects. Overall 26 women
                      $(46.43\%)$ had either a factor V suffering, a prothrombin
                      or MTHFR mutation or were carrier of the PAI 4G/4G
                      polymorphism. Combined genetic defects only occurred with
                      the 4G/4G variant in the PAI gene. Compared to information
                      based on contemporary literature all mutations, except for
                      the MTHFR mutation, occurred more frequently in the study
                      than in the normal population. With regard to a control
                      group of women who had not suffered pregnancy complications,
                      however no significant results could be found. Only the
                      MTHFR mutation occurred significantly less often in the
                      study. The most frequent finding was a higher Factor VIII
                      activity, the PAI 4G/4G polymorphism and a deficiency of
                      Protein S. Despite the fact of having insignificant results
                      and an insufficient number of comparable studies, it can be
                      concluded that women with a premature placental abruption
                      had an above average defect in their coagulation
                      system.Beside studies of association between premature
                      placental abruption and thrombophilia other studies are
                      necessary that should attempt to validate the assumption
                      that microthrombosia of women with a thrombophile
                      constellation can lead to a placental abruption, or to
                      explain how a hypercoagulability can lead to this pregnancy
                      complication. Furthermore, studies are required that analyze
                      and document the impact of a long-term use of lower
                      molecular-heparin on the course of a pregnancy.},
      cin          = {510000-1},
      ddc          = {610},
      cid          = {$I:(DE-82)510000-1_20140620$},
      typ          = {PUB:(DE-HGF)11},
      urn          = {urn:nbn:de:hbz:82-opus-14973},
      url          = {https://publications.rwth-aachen.de/record/60613},
}