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@PHDTHESIS{GnerCapraz:60772,
author = {Güner-Capraz, Nesrin},
othercontributors = {Matern, Siegfried},
title = {{F}atigue und {L}ebensqualität bei {P}atienten mit
chronischer {H}epatitis {C}},
address = {Aachen},
publisher = {Publikationsserver der RWTH Aachen University},
reportid = {RWTH-CONV-122462},
pages = {124 S. : graph. Darst.},
year = {2005},
note = {Aachen, Techn. Hochsch., Diss., 2005},
abstract = {Fatique is the persistent psychic as well as physically
felt tiredness and exhaustion. This symptom goes along with
a serious restriction of the quality of life and is often
observed with patients with a chronic liver illness. The
objective of this work is to examine the fatigue symptom and
its influence on the quality of life, psychic load and
cognitive abilities with patients with chronic hepatitis C.
In the present study 46 patients with chronic hepatitis C,
13 patients with chronic hepatitis B, 22 patients with not
virale hepatitis were enclosed and compared to control group
with a chronically not hepatic illness 32 patients with a
chronically inflammatory intestinal illness (Morbus Crohn or
Colitus ulcerosa). A second control group consists of 38
healthy test persons. Patients and controls completed an
self-report questionnaire with a total of 11 different tests
(3 tiredness tests: Visual Analog Scale, Fatigue Severity
Scale, Fatigue Impact Scale; 2 tests for the judgement of
psychic load: Beck Depression Inventory, Symtom Check Liste;
1 test for the judgement of cognitive deficits: Fragebogen
erlebter Aufmerksamkeitsdefizite; 5 tests for the judgement
of the quality of life: Modulares System zur
Lebensqualität, Fragen zur Lebenszufriedenheit, Nottingham
Health Profile, Befindlichkeitsliste, Beschwerdeliste). As a
function of subjectively felt tiredness the evaluation
occurred for every illness group after allocation of the
patients in subgroups with and without subjective tiredness.
Regardless of the etiology of the illness, $50-60\%$ of all
patients showed a subjective fatigue symptom, which could
well be proved in the fatigue tests. Therefore the tiredness
is neither liver nor hepatitis C specific, but can appear as
a result of a chronic illness. Subjectively felt tiredness
leads in the Fatigue Impact Scale to an interference of the
physical, cognitive and psychosocial functions. The
chronically inflammatory intestinal illness shows in
comparison to chronic liver illness regardless of the
tiredness a decrease of the energy and physical
interference. Subjective tiredness and depression show
moderate to good correlation for patients with chronic
hepatitis C and not virale hepatitis. In contrast, a
depression independent of the subjective tiredness was
ascertained moreover with the chronically inflammatory
intestinal illness. The cognitive efficiency showed in the
group of the chronic hepatitis C with subjective tiredness
the highest self-experienced deficits. Cognitive
interferences also show the comparative group of the Morbus
of Crohn/Colitis patients, so that these deficits are not
specific for liver. An interference of most aspects of the
quality of life was to be observed with chronic hepatitis C
only in the subgroup with subjective tiredness, while the
subgroup without tiredness does not differ in the quality of
life from a healthy control group. Besides, an increase of
the depression and the tiredness resulted in a clear
reduction of the quality of life. However, a restriction of
the quality of life also counts to the other forms of the
chronic hepatitis C if a subjective tiredness persist. The
patients without tiredness are essentially not limited in
their quality of life in spite of their chronic liver
illness. By contrast a decrease of the quality of life can
be ascertained in the comparative group of the chronically
inflammatory intestinal illnesses widely independently of
the subjective tiredness. Hence, for the diagnostics and
therapy of the chronic hepatitis C illness it is crucial to
recognize depressive symptoms and mental changes with the
patients, because an important role comes up to them in the
pathogeny of the tiredness.},
cin = {510000-1},
ddc = {610},
cid = {$I:(DE-82)510000-1_20140620$},
typ = {PUB:(DE-HGF)11},
urn = {urn:nbn:de:hbz:82-opus-13501},
url = {https://publications.rwth-aachen.de/record/60772},
}
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