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@PHDTHESIS{Houben:61229,
author = {Houben, Beate},
othercontributors = {Conrads, Georg},
title = {{I}n-vitro-{S}tudie über die {W}irksamkeit der
{B}acteriocine von {S}treptococcus salivarius zur
{I}nhibition von {S}treptococcus pyogenes},
address = {Aachen},
publisher = {Publikationsserver der RWTH Aachen University},
reportid = {RWTH-CONV-122907},
pages = {89 S. : Ill., graph. Darst.},
year = {2006},
note = {Aachen, Techn. Hochsch., Diss., 2006},
abstract = {This dissertation concentrates on an alternative mechanism
of inhibition of the human pathogenic bacterium S. pyogenes
by use of a probiotic, that is in administration in New
Zealand since almost four years. This probiotic named
“Throat Guard” contains S. salivarius ssp. salivarius
K12 and its bacteriocin Salivaricin A2 in the form of
lozenges , that protect against pharyngeal infections and
rare complications as the acute rheumatic fever and the
acute glomerulonephritis. Because of the broad range of S.
pyogenes serotypes predominant strains that occur in Germany
should be tested upon their susceptibility to the
bacteriocin. For these purposes we arranged in-vitro tests
in liquid media and on solid ground to give consideration to
the physiological conditions in the pharynx with its mucous
membranes and saliva. In liquid media S. salivarius ssp.
salivarius K12 was cultured in different ratios of 20:1, 2:1
and 1:1 to the antagonistic patogen to find out the
dominating bacterium (K12 or S. pyogenes). Furthermore more
than 80 S. pyogenes strains were examined via deferred
antagonism tests on Columbia Agar plates to detect an
inhibition potential by S. salivarius ssp. salivarius K12.
All strains, less invasive strains as well as fatal
pathogens, were identically susceptible to the bacteriocin.
No resistances could be detected; merely a reversible
adaption towards the inhibitory substance could be detected.
Other S. salivarius strains were proved to be less or even
not able to inhibit the pyogenic bacteria. Thus the
investigations of this dissertation affirm the efficacy of
this new dietary supplement that is applied in New Zealand
as an alternative treatment of S. pyogenes infections. So
the immense investments to establish a vaccination against
S. pyogenes and the risk of developing an autoimmunity and
of an increasing resistance to antibiotics could be
minimized. In the meantime a S. salivarius ssp. salivarius
K12 containing mouthwash is prearranged in Germany, too. But
the appliance of bacteria in the form of lozenges or drugs
in general still remains difficult in our country.},
keywords = {Strepococcus salivarius (SWD) / Probiotikum (SWD) /
Streptococcus pyogenes (SWD)},
cin = {510000-1},
ddc = {610},
cid = {$I:(DE-82)510000-1_20140620$},
typ = {PUB:(DE-HGF)11},
urn = {urn:nbn:de:hbz:82-opus-15859},
url = {https://publications.rwth-aachen.de/record/61229},
}
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