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%0 Thesis %A Friedrich, Katharina %T Intrazelluläre Lokalisation und Targeting von ASIC4 %I Rheinisch-Westfälische Technische Hochschule Aachen %V Dissertation %C Aachen %M RWTH-2016-06711 %P 1 Online-Ressource (VII, 74 Seiten) : Illustrationen, Diagramme %D 2016 %Z Veröffentlicht auf dem Publikationsserver der RWTH Aachen University %Z Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2016 %X Acid-sensing ion channels (ASICs) are proton-sensitive, voltage-independent and amiloride-sensitive sodium channels of the DEG/ENaC gene family. ASIC4 is a member of the ASIC family, and which mRNA is expressed in the central nervous system. The strongest localisation of ASIC4-mRNA is found in the pituitary gland. In contrast to other ASICs, ASIC4 can not be activated by protons. Furthermore, ASIC4 comprises only a rather low sequence identity with other ASICs of about 45 %F PUB:(DE-HGF)11 %9 Dissertation / PhD Thesis %U https://publications.rwth-aachen.de/record/668346