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TY - THES AU - Friedrich, Katharina TI - Intrazelluläre Lokalisation und Targeting von ASIC4 PB - Rheinisch-Westfälische Technische Hochschule Aachen VL - Dissertation CY - Aachen M1 - RWTH-2016-06711 SP - 1 Online-Ressource (VII, 74 Seiten) : Illustrationen, Diagramme PY - 2016 N1 - Veröffentlicht auf dem Publikationsserver der RWTH Aachen University N1 - Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2016 AB - Acid-sensing ion channels (ASICs) are proton-sensitive, voltage-independent and amiloride-sensitive sodium channels of the DEG/ENaC gene family. ASIC4 is a member of the ASIC family, and which mRNA is expressed in the central nervous system. The strongest localisation of ASIC4-mRNA is found in the pituitary gland. In contrast to other ASICs, ASIC4 can not be activated by protons. Furthermore, ASIC4 comprises only a rather low sequence identity with other ASICs of about 45 LB - PUB:(DE-HGF)11 UR - https://publications.rwth-aachen.de/record/668346 ER -