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@PHDTHESIS{Lax:674472,
      author       = {Lax, Christian},
      othercontributors = {Walcher, Sebastian and Frank, Martin},
      title        = {{A}nalyse und asymptotische {A}nalyse von
                      {K}ompartimentsystemen},
      school       = {RWTH Aachen University},
      type         = {Dissertation},
      address      = {Aachen},
      reportid     = {RWTH-2016-09465},
      pages        = {1 Online-Ressource (xi, 268 Seiten) : Illustrationen,
                      Diagramme},
      year         = {2016},
      note         = {Veröffentlicht auf dem Publikationsserver der RWTH Aachen
                      University; Dissertation, RWTH Aachen University, 2016},
      abstract     = {This thesis deals with singularly disturbed systems of
                      differential equations. The primary goal is the computation
                      of asymptotic reductions which help with the analysis of
                      those systems. The reductions are based on the classical
                      theories by Tikhonov and Fenichel and thus are referred to
                      as Tikhonov-Fenichel reductions.The thesis consists of two
                      parts. The first part discusses autonomous ODEs and focuses
                      on modelling chemical reactions subjected to quasi steady
                      state assumptions.Therefore, most of the results refer to
                      rational or polynomial systems. Building on the work of Lena
                      Nöthen and Alexandra Goeke, three main results are proven:
                      First of all, Hoppensteadt's theorem can be generalized to
                      systems which are not in Tikhonov normal form. Moreover, a
                      reformulation of the assumptions of the theorem helps to
                      gain a better applicability. Secondly, we can compute
                      Tikhonov-Fenichel reductions for all chemical reaction
                      networks which can be divided into slow and fast reactions,
                      as long as the fast part consists of weakly reversible
                      reactions of first order. The third result refers to
                      compartmental systems, i.e. systems that are governed by
                      transport between subsystems and interaction within these
                      subsystems. It turns out that Tikhonov-Fenichel reductions
                      of those systems can be derived from the individual
                      interaction terms alone.The second part of the thesis
                      discusses asymptotic reductions of reaction diffusion
                      systems. As there is no counterpart to Tikhonov's theorem in
                      infinite dimensions, the main goal is finding and computing
                      explicit reductions of reaction diffusion systems (without
                      giving general convergence results). We do this by
                      considering spatially discretized reaction-diffusion systems
                      as compartmental systems. Our method is backed by various
                      results: First and foremost, we show the consistency of the
                      proposed reduction. Furthermore, a convergence result is
                      proved for reaction diffusion systems for which every
                      reaction is of first order and the fast part satisfies the
                      principle of detailed balance. Lastly, we discuss some
                      examples of which the Michaelis-Menten reaction is the most
                      prominent one. We compare our heuristical reduction of these
                      examples to known results in the literature and discuss
                      systems where no previous results seem to be known. In the
                      latter case, numerical simulations exhibit nice convergence
                      properties.},
      cin          = {114110 / 110000},
      ddc          = {510},
      cid          = {$I:(DE-82)114110_20140620$ / $I:(DE-82)110000_20140620$},
      typ          = {PUB:(DE-HGF)11},
      urn          = {urn:nbn:de:hbz:82-rwth-2016-094653},
      doi          = {10.18154/RWTH-2016-09465},
      url          = {https://publications.rwth-aachen.de/record/674472},
}