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@PHDTHESIS{Wen:713112,
      author       = {Wen, Jian},
      othercontributors = {Bolm, Carsten and Enders, Dieter},
      title        = {{C}opper-catalyzed dealkylations and rhodium-catalyzed
                      {C}−{H} functionalizations of {NH}-sulfoximines},
      school       = {RWTH Aachen University},
      type         = {Dissertation},
      address      = {Aachen},
      reportid     = {RWTH-2018-00926},
      pages        = {1 Online-Ressource (III, 127 Seiten) : Illustrationen},
      year         = {2018},
      note         = {Veröffentlicht auf dem Publikationsserver der RWTH Aachen
                      University; Dissertation, RWTH Aachen University, 2018},
      abstract     = {In recent years, functionalizations of sulfoximines have
                      attracted much attention because of interesting biological
                      activities of the resulting products. For example, to novel
                      heterocycles. In this thesis, the three types of
                      functionalizations of NH-sulfoximines for the construction
                      of sulfonimidamides, 1,2-benzothiazine 1-oxides and
                      1,2-benzothiazepine 1-oxides are presented. Firstly,
                      copper-catalyzed dealkylation/amination sequences which
                      provides sulfonimidamides from NH-sulfoximines under an
                      atmosphere of dioxygen. A wide range of sulfoximines were
                      tolerated affording the corresponding products in moderate
                      to good yields. Mechanistic studies suggested the
                      involvement of radicals in both the C–S bond cleavage and
                      the formation of the new N–S bond. Then, 4-unsubstituted
                      1,2-benzothiazines were prepared from NH-sulfoximines and
                      allyl methyl carbonate by Rh(III)-catalyzed domino
                      allylation/oxidative cyclization. The reaction exhibited a
                      broad scope with respect to NH-sulfoximines. A plausible
                      mechanism was proposed, and chemical potential of the
                      products has been demonstrated by some functionalization
                      reactions. In the last part of the work, Rh(III)-catalyzed
                      [4 + 3] annulations of NH-sulfoximines with
                      α,β-unsaturated ketones leading to 1,2-benzothiazepine
                      1‑oxides was presented. For a wide range of substrates
                      with various functional groups, product were obtained in
                      moderate to good yields. A mechanistic scheme has been
                      proposed, and the oxidative cleavage of the double bond in
                      the heterocycle was demonstrated.},
      cin          = {152920 / 150000},
      ddc          = {540},
      cid          = {$I:(DE-82)152920_20140620$ / $I:(DE-82)150000_20140620$},
      typ          = {PUB:(DE-HGF)11},
      doi          = {10.18154/RWTH-2018-00926},
      url          = {https://publications.rwth-aachen.de/record/713112},
}