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TY  - THES
AU  - Norda, Stephen
TI  - Apolipoprotein E genotype in very preterm neonates with intrauterine growth restriction : an analysis of the German neonatal network cohort
PB  - RWTH Aachen University
VL  - Dissertation
CY  - New York [u.a.]
M1  - RWTH-2018-224211
SP  - 1 Online-Ressource (8 Seiten) : Illustrationen, Diagramme
PY  - 2017
N1  - Veröffentlicht auf dem Publikationsserver der RWTH Aachen University
N1  - Dissertation, RWTH Aachen University, 2018
AB  - Aim. Cord blood of intrauterine growth restricted (IUGR) neonates displays lipid changes towards atherosclerotic profiles. Apolipoprotein E (ApoE) and its isoforms (e2, e3, and e4) are involved in the regulation of lipid metabolism. Specifically, ApoE e4has been associated with atherosclerotic diseases, while e2 has a favorable effect. We therefore hypothesized that ApoE e4 haplotypeis frequently observed in IUGR neonates and contributes to impaired fetal growth and the association of IUGR with cardiovascular and metabolic diseases later in life. Methods. A cohort of 4885 preterm infants (≥22+0 and <32+0 weeks of gestation and birthweight below 1500 g) from the GNN study cohort was analyzed. Neonates were categorized into subgroups of <3rd, 3rd-10th, and>10th birth weight percentile. Analysis of the single nucleotides rs429358 and rs7412, identifying the ApoE genotype, was carried out using TaqMan SNP genotyping assays. The proportional odds model was used to assess data. Results. No association was found between genotype and birth weight percentiles in each of the subgroups. Conclusion. ApoE genotype and low birth weight depict two distinct risk factors for cardiovascular disease without being directly associated.
LB  - PUB:(DE-HGF)11
DO  - DOI:10.18154/RWTH-2018-224211
UR  - https://publications.rwth-aachen.de/record/723458
ER  -