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TY  - THES
AU  - Yang, Danqing
TI  - Characterization of synaptic connections and cholinergic modulation of layer 6A microcircuitry in rat barrel cortex
PB  - RWTH Aachen University
VL  - Dissertation
CY  - Aachen
M1  - RWTH-2018-230346
SP  - 1 Online-Ressource (109 Seiten) : Illustrationen, Diagramme
PY  - 2018
N1  - Veröffentlicht auf dem Publikationsserver der RWTH Aachen University 2019
N1  - Dissertation, RWTH Aachen University, 2018
AB  - Of all neocortical layers, layer 6 is the least studied layer that shows a relatively high neuronalheterogeneity and low intralaminar connectivity. Layer 6A provides direct projections from corticothalamic(CT) pyramidal cells to both VPM and POM nucleus of the thalamus and are thus integral part of a thalamo-cortical-thalamic feedback loop that controls sensory signalling. In this study, we investigated anatomical and functional properties of L6A intra-laminar excitatory and inhibitory connections in L6A of rat barrel cortex by performing dual whole-cell recordings with simultaneousbiocytin fillings. The neuronal morphology was subsequently reconstructed and putative CT andcortico-cortical (CC) pyramidal cells were distinguished based on their distinct axonal projection patterns. An unsupervised cluster analysis were performed to classify FS and nFS interneurons based on their electrophysiological properties such as membrane properties and firing properties. Thus, different types of connections were identified based on pre- and postsynaptic neuronalsubtypes. The intralaminar connectivity of L6A neurons is low with a connectivity ratio of 6.5
LB  - PUB:(DE-HGF)11
DO  - DOI:10.18154/RWTH-2018-230346
UR  - https://publications.rwth-aachen.de/record/749817
ER  -