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TY  - THES
AU  - Menzel, Miriam
TI  - Finite-difference time-domain simulations assisting to reconstruct the brain's nerve fiber architecture by 3D polarized light imaging
VL  - 188
PB  - RWTH Aachen University
VL  - Dissertation
CY  - Jülich
M1  - RWTH-2018-230974
SN  - 978-3-95806-368-6
T2  - Schriften des Forschungszentrums Jülich, Reihe Schlüsseltechnologien
SP  - ix, 296 S.
PY  - 2018
N1  - Druckausgabe: 2018. - Onlineausgabe: 2018. - Auch veröffentlicht auf dem Publikationsserver der RWTH Aachen University. - Ausgezeichnet mit der Borchers-Plakette.
N1  - Dissertation, RWTH Aachen University, 2018
AB  - The neuroimaging technique Three-dimensional Polarized Light Imaging (3D-PLI) reconstructs the brain’s nerve fiber architecture by transmitting polarized light through histological brain sections and measuring their birefringence. Measurements have shown that the polarization-independent transmitted light intensity (transmittance) depends on the out-of-plane inclination angle of the nerve fibers. Furthermore, the optical anisotropy that causes the birefringence leads to polarization-dependent attenuation of light (diattenuation), which might provide additional information about the underlying fiber configuration. In this thesis, analytical considerations, supplementary measurements, and numerical simulations were performed to study the transmittance and diattenuation effects in more detail, and to develop ideas how the effects can assist the nerve fiber reconstruction with 3D-PLI. The propagation of the polarized light wave through the brain tissue was modeled by Finite-Difference Time-Domain (FDTD) simulations. Following a bottom-up approach, the simplest possible model was identified that describes the observed transmittance and diattenuation effects. The experimental studies in this work have shown that the transmittance significantly decreases with increasing inclination angle of the fibers (by more than 50 
LB  - PUB:(DE-HGF)11 ; PUB:(DE-HGF)3
DO  - DOI:10.18154/RWTH-2018-230974
UR  - https://publications.rwth-aachen.de/record/750948
ER  -