Gast ::
000777746 001__ 777746 000777746 005__ 20230209042440.0 000777746 0247_ $$2CORDIS$$aG:(EU-Grant)841956$$d841956 000777746 0247_ $$2CORDIS$$aG:(EU-Call)H2020-MSCA-IF-2018$$dH2020-MSCA-IF-2018 000777746 0247_ $$2originalID$$acorda__h2020::841956 000777746 035__ $$aG:(EU-Grant)841956 000777746 150__ $$aDe novo design of an UpConverting metalloProtein$$y2019-09-02 - 2021-09-01 000777746 371__ $$aUniversity of Birmingham$$bUniversity of Birmingham$$dUnited Kingdom$$ehttp://www.birmingham.ac.uk/index.aspx$$vCORDIS 000777746 372__ $$aH2020-MSCA-IF-2018$$s2019-09-02$$t2021-09-01 000777746 450__ $$aUCLnProt$$wd$$y2019-09-02 - 2021-09-01 000777746 5101_ $$0I:(DE-588b)5098525-5$$2CORDIS$$aEuropean Union 000777746 680__ $$aHerein, we propose to design de novo (“from scratch”) the first upconverting metalloprotein. This will be achieved by exploiting a new class of lanthanide coiled coils (LCC), to generate bimetallic derivatives. These will, for the first time, combine the attractive photophysical properties of Ln complexes, with de novo designed coiled coil scaffolds capable of selectively binding different Ln ions at well-defined and tuneable distances. This programme of work will provide a new strategy for unlocking the full potential of science at the interface of biology and inorganic chemistry, by combining previously unexplored ligands with traditional inorganic complexes, for applications beyond those offered by biology, such as upconversion. The complementary expertise of Dr Borghesani (bioinorganic chemistry and spectroscopy) and the supervisor Dr Peacock (metallopeptide design) offer the unique combination to realise the full potential of multimetallic LCCs, and will, in conjunction with two planned short secondments, provide Dr Borghesani with new and cutting-edge research training. 000777746 909CO $$ooai:juser.fz-juelich.de:870094$$pauthority$$pauthority:GRANT 000777746 909CO $$ooai:juser.fz-juelich.de:870094 000777746 970__ $$aoai:dnet:corda__h2020::d2436da5c10144e3cc9db3aec32f9dfd 000777746 980__ $$aG 000777746 980__ $$aCORDIS 000777746 980__ $$aAUTHORITY