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000796914 001__ 796914
000796914 005__ 20230211042702.0
000796914 0247_ $$2CORDIS$$aG:(EU-Grant)848146$$d848146
000796914 0247_ $$2CORDIS$$aG:(EU-Call)H2020-SC1-2019-Two-Stage-RTD$$dH2020-SC1-2019-Two-Stage-RTD
000796914 0247_ $$2originalID$$acorda__h2020::848146
000796914 035__ $$aG:(EU-Grant)848146
000796914 150__ $$aA high-dimensional approach for unwinding immune-metabolic causes of cardiovascular disease-depression multimorbidities$$y2020-01-01 - 2024-12-31
000796914 371__ $$aUniversity of Geneva$$bUNIGE$$dSwitzerland$$ehttps://www.unige.ch/$$vCORDIS
000796914 371__ $$aPIRKANMAA HOSPITAL DISTRICT$$bTampere University Hospital$$dFinland$$ehttp://www.pshp.fi$$vCORDIS
000796914 371__ $$aHeidelberg University$$bHeidelberg University$$dGermany$$ehttp://www.uni-heidelberg.de/index_e.html$$vCORDIS
000796914 371__ $$aSOCIETE EUROPEENNE DE CARDIOLOGIE$$bESC/ SEC$$dFrance$$ehttp://www.escardio.org$$vCORDIS
000796914 371__ $$aUniversity Medical Center Utrecht$$bUMC$$dNetherlands$$ehttp://www.umcutrecht.nl/nl/$$vCORDIS
000796914 371__ $$aVU University Amsterdam$$bVU$$dNetherlands$$ehttp://www.vu.nl/en/$$vCORDIS
000796914 371__ $$aUNIVERSYTET MEDYCZNY W LODZI.$$bLODZ$$dPoland$$ehttp://www.umed.lodz.pl$$vCORDIS
000796914 371__ $$aMicronit Microfluidics (Netherlands)$$bMicronit Microfluidics (Netherlands)$$dNetherlands$$vCORDIS
000796914 371__ $$aUniversity Hospital Bonn$$bUniversity Hospital Bonn$$dGermany$$ehttps://www.ukb.uni-bonn.de/$$vCORDIS
000796914 371__ $$aVU University Medical Center$$bVUMC$$dNetherlands$$ehttp://www.vumc.nl/$$vCORDIS
000796914 371__ $$aPANEPISTIMIO IOANNINON$$bUOI$$dGreece$$ehttp://www.uoi.gr / www.rc.uoi.gr$$vCORDIS
000796914 371__ $$aIDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON$$bBIOMEDICAL RESEARCH FOUNDATION, ACADEMY OF ATHENS$$dGreece$$ehttp://www.bioacademy.gr$$vCORDIS
000796914 371__ $$aGENOWAY$$dFrance$$ehttp://www.genoway.com$$vCORDIS
000796914 371__ $$aMARIOS LYMARAKIS KAI SIA EE$$dGreece$$ehttp://www.exelixisrm.com$$vCORDIS
000796914 372__ $$aH2020-SC1-2019-Two-Stage-RTD$$s2020-01-01$$t2024-12-31
000796914 450__ $$aTO_AITION$$wd$$y2020-01-01 - 2024-12-31
000796914 5101_ $$0I:(DE-588b)5098525-5$$2CORDIS$$aEuropean Union
000796914 680__ $$aDepression is a common and serious comorbidity of cardiovascular disease (CVD) affecting one in three patients, among which women earlier and more frequently. Depression increases the risk for CVD development, acute events and mortality by >2 fold, independently of traditional risk factors, and constitutes an enormous socioeconomic burden in terms of morbidity, mortality and healthcare costs. Still, the patients at risk, disease trajectories and causative mechanisms involved remain unknown.
TO_AITION addresses the hypothesis that immune-metabolic dysregulation, occurring as a result of genetic, lifestyle and environmental risk factors ‘training’ innate immunity, drives low grade systemic inflammation leading to the development of CVD-depression comorbidity. 
It integrates basic (cell models, immune-metabolic mechanisms, myeloid cell reprogramming), preclinical (animal models, CRISPR genome editing) and clinical (longitudinal cohorts with comprehensive existing data) research, in order to characterise immune-metabolic mechanisms driving CVD-depression comorbidity. Both hypothesis and data-driven strategies will be employed to address causality, focusing on genetic, epigenetic, transcriptional, metabolic and other disturbances leading to the development of comorbidity. Drug-drug interactions and their effects on causative mechanisms and disease trajectories will also be determined. Pathways identified will be evaluated in cell-based and animal models to prove their causal role and obtain mechanistic insight. Finally, new risk models will be developed, and relevant regulatory, cost-effectiveness and feasibility issues addressed. Effective patient-oriented awareness actions, dissemination, exploitation and management activities are also provisioned.
TO_AITION will therefore rationally change our current understanding of the causative mechanisms driving CVD-depression comorbidity, unravelling patients’ complexity and improving their diagnosis, monitoring and management.
000796914 909CO $$ooai:juser.fz-juelich.de:879361$$pauthority$$pauthority:GRANT
000796914 909CO $$ooai:juser.fz-juelich.de:879361
000796914 970__ $$aoai:dnet:corda__h2020::82b05f60676c62ae82ba286a1f789a5c
000796914 980__ $$aG
000796914 980__ $$aCORDIS
000796914 980__ $$aAUTHORITY