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MIX-UP

MIXed plastics biodegradation and UPcycling using microbial communities

CoordinatorAB Enzymes GmbH ; UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN ; AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ; Forschungszentrum Jülich ; RWTH Aachen University ; University of Greifswald ; BIOPLASTECH LTD ; CNRS - Institut des Sciences Biologiques ; SOPREMA ; PGS PACIFIC GARBAGE SCREENING GMBH
Grant period2020-01-01 - 2023-12-31
Funding bodyEuropean Union
Call numberH2020-NMBP-BIO-CN-2019
Grant number870294
IdentifierG:(EU-Grant)870294

Note: The continuing demand for plastic products, the lack of appropriate recycling and the ubiquitous pollution of the environment with plastic waste pose a global challenge. An ambitious vision and considerable efforts are required to change the traditional value chain of plastics to a sustainable one, based on biodegradable plastics. In MIX-UP, plastic mixtures with five of the top six fossil-based recalcitrant plastics (PP, PE, PUR, PET, and PS), along with upcoming biodegradable plastics such as PLA and PHA, will be used as feedstock for microbial transformations, thereby generating a workflow that increases the recycling quota and adds value to poorly recycled plastics waste streams. Successive controlled enzymatic and microbial degradation of mechanically pre-treated plastics waste will be combined with subsequent microbial conversion to value-added chemicals and polymers by mixed cultures. We will optimize known plastics-degrading enzymes for high specific binding capacities, stability, and catalytic efficacy towards a broad spectrum of plastics polymers under high salt and temperature conditions by integrated protein engineering, and also isolate novel enzymes with activities on recalcitrant polymers. MIX-UP will also optimize the production of enzymes and formulate enzyme cocktails tailored to specific waste streams. Implementation of these enzymes, both in vitro and in vivo, enables stable self-sustaining microbiomes to convert the released plastic monomers selectively into at least six value-added products, key building blocks, and biomass. Any remaining material recalcitrant to enzymatic activity will be recirculated into the process after a physico-chemical treatment. The Chinese-European MIX-UP is a multidisciplinary and industry-driven consortium that addresses the market need for novel sustainable routes to valorise plastics waste streams. MIX-UP realises a circular (bio)-economy and could be a viable alternative for mechanical and chemical recycling.
     

Recent Publications

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Genome mining the black-yeast Aureobasidium pullulans NRRL 62031 for biotechnological traits
BMC genomics 26(1), 244 () [10.1186/s12864-025-11395-2]  GO OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Two-step biocatalytic conversion of post-consumer polyethylene terephthalate into value-added products facilitated by genetic and bioprocess engineering
Bioresource technology 417, 131837 () [10.1016/j.biortech.2024.131837]  GO OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Cultivation optimization promotes ginsenoside and universal triterpenoid production by engineered yeast
New biotechnology 83, 219-230 () [10.1016/j.nbt.2024.08.505]  GO OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Advances in Aureobasidium research : Paving the path to industrial utilization
Microbial biotechnology 17(8), e14535 () [10.1111/1751-7915.14535]  GO OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Establishing a straightforward I-SceI-mediated recombination one-plasmid system for efficient genome editing in P. putida KT2440
Microbial biotechnology 17(7), e14531 () [10.1111/1751-7915.14531]  GO OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Proposal for a systematic naming convention for liamocins
Journal of surfactants and detergents : JSD 27(3), 459-461 () [10.1002/jsde.12735]  GO OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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A Competitive High‐Throughput Screening Platform for Designing Polylactic Acid‐Specific Binding Peptides
Advanced science 10(29), 2303195 () [10.1002/advs.202303195] special issue: "Hot Topic: Automated Synthesis"  GO OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Techno‐Economic Comparison of Bio‐Cycling Processes for Mixed Plastic Waste Valorization
Chemie - Ingenieur - Technik : CIT 95(8), 1247-1258 () [10.1002/cite.202300021] special issue: "Special Issue:Chemisches Recycling von Kunststoffen / Issue Edited by: Philip Biessey"  GO OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Recent Advances in Yeast Recombinant Biosynthesis of the Triterpenoid Protopanaxadiol and Glycosylated Derivatives Thereof
Journal of agricultural and food chemistry 71(5), 2197-2210 () [10.1021/acs.jafc.2c06888]  GO  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Biotechnology Data Analysis Training with Jupyter Notebooks
Journal of microbiology & biology education 24(1), e00113-22 () [10.1128/jmbe.00113-22]  GO OpenAccess  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

All known publications ...
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 Record created 2020-09-05, last modified 2023-02-09
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