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TY  - THES
AU  - Anand, Deepak
TI  - Chiral separation of arginine based on tailor-made FhuA β-barrel protein
PB  - RWTH Aachen University
VL  - Dissertation
CY  - Aachen
M1  - RWTH-2021-03346
SP  - 1 Online-Ressource : Illustrationen, Diagramme
PY  - 2020
N1  - Veröffentlicht auf dem Publikationsserver der RWTH Aachen University 2021
N1  - Dissertation, RWTH Aachen University, 2020
AB  - Chirality of chemical compound is ubiquitous in nature performing central function in metabolism of many nutrients and pharmaceuticals. Even-though enantiomers of a compound have similar chemical and physical properties it can have completely different biological activity. Thus chiral molecules are of large economic value in chemical, pharmaceutical, and food industries. Many applications in these industries require the isolation and use of single chiral isomers (enantiomers) of chiral compounds. As a result, there is an ever increasing necessity of optically pure compounds but it is a challenging task to obtain it. Since the first optical resolution of tartaric acid, performed by Louis Pasteur in early 1848, various techniques have been developed for chiral resolutions of enantiomeric compounds. Methods such as chromatographic or enzymatic techniques are commonly used. However, they are limited by difficulties for large-scale productions. Crystallization can be used in large-scales but often several rounds of crystallization and recrystallization are required to obtain enantiopure compounds due to entrapments of the unwanted enantiomer during crystal growth, which often leads to significant reduction in yields (up to 50 
LB  - PUB:(DE-HGF)11
DO  - DOI:10.18154/RWTH-2021-03346
UR  - https://publications.rwth-aachen.de/record/816648
ER  -