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@PHDTHESIS{vonderStck:82858,
author = {von der Stück, Hannah},
othercontributors = {Seghaye, Marie-Christine},
title = {{S}tellenwert von {I}nterleukin-6 als {M}arker der
postoperativen {M}orbidität nach {H}erzoperationen im
{K}indes- und {J}ugendalter},
address = {Aachen},
publisher = {Publikationsserver der RWTH Aachen University},
reportid = {RWTH-CONV-143214},
pages = {VII, 67 S. : graph. Darst.},
year = {2012},
note = {Aachen, Techn. Hochsch., Diss., 2012},
abstract = {BACKGROUND AND OBJECTIVES: The important proinflammatory
cytokine IL-6 has been a subject of research for many years.
It has been demonstrated that IL-6 plays a pivotal role in
the emergence of a multi-organ dysfunction syndrome (MODS)
after surgery with ECC. Based on the known correlations
between IL-6 and the pathophysiology of MODS, the aim of our
study was to investigate whether IL-6 may serve as a marker
of postoperative MODS.METHODS: 58 children with a congenital
heart defect who were operated between May 2004 and November
2005 in the University Hospital of the RWTH - Aachen were
included. The operations were all performed using the HLM.
The postoperative clinical data were documented in
standardized scores. The blood samples for determination of
IL-6 were taken at specific points in time. The
determination was performed by ELISA. The collected data
were analyzed by SPSS.RESULTS: A maximum of IL-6 was
measured immediately after surgery. Then the level steadily
decreased in a period of 24 hours postoperatively. The IL-6
plasma concentrations also correlated with the duration of
surgery and the intraoperative hypothermia. Furthermore, our
data show that the serum concentration of IL-6 influences
various organ systems in the postoperative course. The
relationship between cardiac function and IL-6
concentrations in plasma, which has already been well
examined, was confirmed by our data. Also, pulmonary
impairments could be detected in patients with elevated IL-6
levels. Our data confirm that renal dysfunction may be due
to high IL-6 levels.CONCLUSIONS: Our work clearly
demonstrates that IL-6 in the postoperative course of
children with congenital heart defect operated under ECC,
does not only influence single organ systems, but the whole
organism.The use of IL-6 as a marker of postoperative
healing process of children who were operated under ECC
because of a congenital heart defect may be useful. Further
research efforts for detailed examination of the qualitiy of
IL-6 as a marker may allow a useful integration of IL-6
determinations into clinical routine.},
keywords = {Cytokine (SWD) / Interleukin 6 (SWD) / Herz-Lungen-Maschine
(SWD) / Extrakorporaler Kreislauf (SWD) / Kind (SWD) /
Allgemeine Entzündungsreaktion (SWD)},
cin = {537520-2},
ddc = {610},
cid = {$I:(DE-82)537520-2_20140620$},
typ = {PUB:(DE-HGF)11},
urn = {urn:nbn:de:hbz:82-opus-42403},
url = {https://publications.rwth-aachen.de/record/82858},
}
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