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%0 Thesis %A Ott, Veronica %T Der Einfluss von Antiseptika auf mesenchymale adipogene Stammzellen %I Rheinisch-Westfälische Technische Hochschule Aachen %V Dissertation %C Aachen %M RWTH-2021-10006 %P 1 Online-Ressource : Illustrationen, Diagramme %D 2021 %Z Veröffentlicht auf dem Publikationsserver der RWTH Aachen University %Z Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2021 %X Antiseptics are so important and omnipresent on the daily routine of every medical institution, such that it is difficult to imagine medical practice without them. They are used to disinfect wounds or parts of the body both before, during and afterwards surgery, creating a broad antimicrobial effect. The adipose tissue fulfils many functions for the human body, ranging from serving as an energy store, being a structural component as well as providing temperature insulation. In addition, antiseptics have an influence on the hormonal balance and help regulating the wound healing process. The major cell type of this tissue are mesenchymal stem cells (MSZ), which are the regenerative resource of this tissue. Numerous in vivo and in vitro studies on the cytotoxicity of antiseptics on cells of the skin and other tissues have already been carried out, but none yet devoted to the effect on the adipose tissue. Therefore, this project investigates the cytotoxicity of various commercial antiseptics. We selected a broad sweep of antiseptics, which are used in a wide range of medical fields, to compare and contrast. We also chose some, who are more specific to the field of plastic, reconstructive and burn surgery, such as Mafenid, a topical antibiotic. The results of the investigation were, that Octenisept® (an antiseptic, that is one of the most frequently used substances for disinfection) had the most cytotoxic effect on the MSZ. The substance was already highly cytotoxic in the lowest concentrations tested. The antiseptics Betaisodona®, and Prontosan® and Lavasept® were located in the middle range of cytotoxity, but they all still showed cytotoxic effects at a concentration of 7.5 %F PUB:(DE-HGF)11 %9 Dissertation / PhD Thesis %R 10.18154/RWTH-2021-10006 %U https://publications.rwth-aachen.de/record/834586