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@PHDTHESIS{Bleidorn:853629,
      author       = {Bleidorn, Johannes},
      othercontributors = {Martin, Christian and Kraus, Thomas},
      title        = {{T}he pro-inflammatory stimulus of zinc- and
                      copper-containing welding fumes in whole blood assay via
                      protein tyrosine phosphatase 1{B} inhibition},
      school       = {Rheinisch-Westfälische Technische Hochschule Aachen},
      type         = {Dissertation},
      address      = {Aachen},
      publisher    = {RWTH Aachen University},
      reportid     = {RWTH-2022-08980},
      pages        = {1 Online-Ressource},
      year         = {2022},
      note         = {Veröffentlicht auf dem Publikationsserver der RWTH Aachen
                      University; Dissertation, Rheinisch-Westfälische Technische
                      Hochschule Aachen, 2022},
      abstract     = {An asymptomatic systemic inflammation after exposure to
                      zinc- and copper-containing welding fumes has been described
                      as mild form of metal fume fever in recent studies. Since
                      chronic systemic inflammation leads to a higher
                      cardiovascular risk, examining the inflammation with its
                      underlying pathomechanism is necessary to estimate and
                      hopefully prevent long-term effects of welding. We
                      established a whole blood assay to investigate the effects
                      of zinc- and copper-containing welding fume particles on the
                      blood immune response. Increased levels of IL-6, IL-8, TNFα
                      and IL-1β, determined after 24 hours of exposure indicated
                      an acute systemic inflammatory reaction. In vitro levels of
                      IL-6 were comparable to in vivo increases of serum IL-6
                      levels in a study with welding fume exposure of human
                      subjects. Inhibition of PTP1B was identified as one pathway
                      responsible for the effects of zinc- and copper-containing
                      welding fumes and therefore welding fume fever. In
                      conclusion, the whole blood assay is a reliable and feasible
                      method to investigate effects of zinc- and copper-containing
                      welding fumes on the immune system and as surrogate for
                      systemic inflammation and welding fume fever. Future
                      research can utilize whole blood assays to reduce and
                      partially replace human exposure studies for further
                      investigations of welding fume fever.},
      cin          = {528500-2},
      ddc          = {610},
      cid          = {$I:(DE-82)528500-2_20140620$},
      typ          = {PUB:(DE-HGF)11},
      doi          = {10.18154/RWTH-2022-08980},
      url          = {https://publications.rwth-aachen.de/record/853629},
}