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%0 Thesis
%A Puccetti, Francesco
%T Mechanochemistry of small organic molecules : Synthetic applications and monitoring protocols
%I RWTH Aachen University
%V Dissertation
%C Aachen
%M RWTH-2023-01148
%P 1 Online-Ressource : Illustrationen, Diagramme
%D 2023
%Z Veröffentlicht auf dem Publikationsserver der RWTH Aachen University
%Z Dissertation, RWTH Aachen University, 2023
%X In recent decades, organic synthesis techniques have seen a crescent interest in the application of mechanochemical methods. In parallel with values of a reduced environmental impact, such methodologies have shown the possibility of developing reactivities otherwise unobtainable by other synthetic approaches. For this reason, ad-hoc monitoring techniques compatible with the mechanical needs of the mechanochemical reactors have been developed. This thesis entitled "Mechanochemistry of Small Organic Molecules: Synthetic Applications and Monitoring Protocols" aims to contribute to both the fields of mechanosynthetic applications and monitoring techniques for mechanically induced molecular interactions. A first part of the work reports the development and application of mechanochemical synthetic procedures, specifically being: the use of raw minerals as a source of catalytic species for metal-catalyzed reaction, the study of a mechanochemical cross dehydrogenative coupling reaction, and a mechanosynthetic bottom-up protocol for the synthesis of unsymmetric triarylamines from primary aryl amines. In a second part, the application of in-situ Raman monitoring techniques is used to discern the mechanism involved in the mechanosynthesis of the active pharmaceutical ingredient phenytoin, followed by the presentation of an NMR in-operando method for the analysis of mechanochemically accelerated sublimations.
%F PUB:(DE-HGF)11
%9 Dissertation / PhD Thesis
%R 10.18154/RWTH-2023-01148
%U https://publications.rwth-aachen.de/record/889590