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%0 Thesis
%A Sommer, David
%T Koordinationsverbindungen neuartiger C<sub>2</sub>- und C<sub>3</sub>-symmetrischer Liganden mit Ti(IV), Fe(III), Y(III) und Zr(IV) für die Anwendung als Radiopharmaka
%I RWTH Aachen University
%V Dissertation
%C Aachen
%M RWTH-2023-11813
%P 1 Online-Ressource : Illustrationen
%D 2023
%Z Veröffentlicht auf dem Publikationsserver der RWTH Aachen University 2024
%Z Dissertation, RWTH Aachen University, 2023
%X The present dissertation, entitled „Coordination Complexes of novel C<sub>2</sub> and C<sub>3</sub> symmetric ligands with Ti(IV), Fe(III), Y(III) and Zr(IV) for application as radiopharmaceuticals”, focuses on the development and characterization of innovative chelators featuring catechol groups, designed to selectively form coordination complexed, particularly with Ti(IV) and Zr(IV). The C<sub>2</sub> symmetric ligands are based on dipicolinic acid or chelidamic acid, incorporating flexible linkers with imine groups for binding to the catechol functions. Their selective reactions with Fe(III) and Y(III) for the formation of coordination dimers is discussed. Additionally, discrete complexes resulting from reactions with various Zr(IV) salts are described in detail. A critical examination of the possibilities and limitations of employing these ligands, especially in the medical context as radiopharmaceuticals for PET scans, leads to ligand optimization towards C<sub>3</sub> symmetric imine ligands based on TREN.Subsequent experiments elucidate, how these ligands can react with titanium compounds into monometallic, cationic, or heterobimetallic titanium complexes. A discussion on the stability of the imine bond under physiological conditions ultimately leads to the conceptualization of a final ligand model based on amine groups instead of imine groups. It is demonstrated that their reaction with Ti(IV) precursors can be controlled by adequate basicity, enabling the selective formation of either monometallic titanium coordination compounds or heterobimetallic Ti-Ca-complexes, which could be promising radiopharmaceuticals for PET scan after <sup>45</sup>Ti labeling.Consideration of additional functional groups for potential binding to biomolecules for specific tissue targeting is also addressed.In summary, this work encompasses a comprehensive discussion of eight newly developed chelators and two ligands already known in the literature, along with their new coordination complexes with Fe(III), Y(III), Zr(IV) and primarily Ti(IV), including the presentation of 25 new crystal structures.
%F PUB:(DE-HGF)11
%9 Dissertation / PhD Thesis
%R 10.18154/RWTH-2023-11813
%U https://publications.rwth-aachen.de/record/975078