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@PHDTHESIS{Sommer:975078,
author = {Sommer, David},
othercontributors = {Oppel, Iris Marga and Albrecht, Markus},
title = {{K}oordinationsverbindungen neuartiger ${C}_{2}$- und
${C}_3$-symmetrischer {L}iganden mit {T}i({IV}),
{F}e({III}), {Y}({III}) und {Z}r({IV}) für die {A}nwendung
als {R}adiopharmaka},
school = {RWTH Aachen University},
type = {Dissertation},
address = {Aachen},
publisher = {RWTH Aachen University},
reportid = {RWTH-2023-11813},
pages = {1 Online-Ressource : Illustrationen},
year = {2023},
note = {Veröffentlicht auf dem Publikationsserver der RWTH Aachen
University 2024; Dissertation, RWTH Aachen University, 2023},
abstract = {The present dissertation, entitled „Coordination
Complexes of novel $C_2$ and $C_3$ symmetric ligands with
Ti(IV), Fe(III), Y(III) and Zr(IV) for application as
radiopharmaceuticals”, focuses on the development and
characterization of innovative chelators featuring catechol
groups, designed to selectively form coordination complexed,
particularly with Ti(IV) and Zr(IV). The $C_2$ symmetric
ligands are based on dipicolinic acid or chelidamic acid,
incorporating flexible linkers with imine groups for binding
to the catechol functions. Their selective reactions with
Fe(III) and Y(III) for the formation of coordination dimers
is discussed. Additionally, discrete complexes resulting
from reactions with various Zr(IV) salts are described in
detail. A critical examination of the possibilities and
limitations of employing these ligands, especially in the
medical context as radiopharmaceuticals for PET scans, leads
to ligand optimization towards $C_3$ symmetric imine ligands
based on TREN.Subsequent experiments elucidate, how these
ligands can react with titanium compounds into monometallic,
cationic, or heterobimetallic titanium complexes. A
discussion on the stability of the imine bond under
physiological conditions ultimately leads to the
conceptualization of a final ligand model based on amine
groups instead of imine groups. It is demonstrated that
their reaction with Ti(IV) precursors can be controlled by
adequate basicity, enabling the selective formation of
either monometallic titanium coordination compounds or
heterobimetallic Ti-Ca-complexes, which could be promising
radiopharmaceuticals for PET scan after $^{45}$Ti
labeling.Consideration of additional functional groups for
potential binding to biomolecules for specific tissue
targeting is also addressed.In summary, this work
encompasses a comprehensive discussion of eight newly
developed chelators and two ligands already known in the
literature, along with their new coordination complexes with
Fe(III), Y(III), Zr(IV) and primarily Ti(IV), including the
presentation of 25 new crystal structures.},
cin = {151520 / 150000},
ddc = {540},
cid = {$I:(DE-82)151520_20140620$ / $I:(DE-82)150000_20140620$},
typ = {PUB:(DE-HGF)11},
doi = {10.18154/RWTH-2023-11813},
url = {https://publications.rwth-aachen.de/record/975078},
}
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