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@PHDTHESIS{Motta:977990,
      author       = {Motta, Alessandro},
      othercontributors = {Lammers, Twan and Bartneck, Matthias},
      title        = {3{D}-printed phantoms for evaluating sensitivity and
                      detection limits of fluorophore-labelled nanomedicines in
                      {FMT}/{CT} imaging},
      school       = {Rheinisch-Westfälische Technische Hochschule Aachen},
      type         = {Dissertation},
      address      = {Aachen},
      reportid     = {RWTH-2024-01048},
      pages        = {100 Seiten : Illustrationen},
      year         = {2024},
      note         = {Dissertation, Rheinisch-Westfälische Technische Hochschule
                      Aachen, 2024},
      abstract     = {This thesis describes the prototyping of custom phantoms
                      for assessing the sensitivity and detection limits of
                      contrast agents via fluorescence reflectance imaging (FRI)
                      and fluorescence-mediated tomography combined with
                      micro-computed tomography (FMT/CT). The optical imaging
                      agent employed was a nano-scale liposome formulation labeled
                      with the near-infrared (NIR) fluorophore Cy7, with a
                      clinically relevant composition and used at representative
                      preclinical concentrations. Computer-aided modeling and
                      3D-printing techniques were employed to manufacture
                      multi-channel phantoms with different thermoplastic
                      materials, and subsequently, to recognize the low-end
                      detection limit of the FMT/CT system, as well as to define
                      its detection sensitivity by scanning various broad and
                      narrow concentration ranges of the Cy7-nanoformulation. The
                      multi-channel phantom facilitated the rapid acquisition and
                      data collection in comparison to single-well phantoms. In
                      addition, considering the different optical properties of
                      the materials used for 3D printing, constructs composed of
                      different materials were systematically scanned for their
                      optical features by spectrophotometry. As a final proof of
                      concept, mouse whole-body and key organ (heart, liver)
                      segmentation from an in vivo dataset were averaged to
                      extract relevant shapes and volumes, in order to generate a
                      3D-printed mouse-like phantom with removable and contrast
                      agent- fillable organs, thereby allowing for simulation of
                      fluorescence detection in organs relevant for assessing
                      nanoparticle performance in vivo. Altogether, this thesis
                      integrates 3D-printing approaches together with optical
                      imaging analysis via FRI, FMT/CT and spectrophotometry for
                      manufacturing and evaluating biomimetic phantoms towards the
                      assessment of the sensitivity and detection limits of NIR
                      probes and NIR-labelled nanomedicine formulations.},
      cin          = {811003-3 ; 924210},
      ddc          = {610},
      cid          = {$I:(DE-82)811003-3_20140620$},
      pnm          = {NRW EFRE-0801767 - Taktira (EFRE-0801767) / Meta-Targeting
                      - Macro-Nanomedicine to Treat Metastatic Cancer (864121)},
      pid          = {G:(NRW)EFRE-0801767 / G:(EU-Grant)864121},
      typ          = {PUB:(DE-HGF)11},
      url          = {https://publications.rwth-aachen.de/record/977990},
}