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TY  - THES
AU  - Chen, Ze
TI  - Associations of serum CXCL12ɑ and IL-16 levels with sarcopenia in older adults
PB  - Rheinisch-Westfälische Technische Hochschule Aachen
VL  - Dissertation
CY  - Aachen
M1  - RWTH-2024-05490
SP  - 12, 12 Seiten : Illustrationen, Diagramme
PY  - 2024
N1  - Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2024, Kumulative Dissertation
AB  - Sarcopenia, a condition characterized by gradual loss of skeletal muscle mass and function, is a complex diagnosis; the decisive criterion in this diagnosis is the measurement of appendicular skeletal muscle index (ASMI). To identify potential serum markers predictive of sarcopenia in older adults, we evaluated correlations of 80 older adults between ASMI, clinical data, and a total of 68 serum inflammation markers in two consecutive analyses. Pearson’s correlation analyses confirmed that ASMI was positively correlated with nutritional status (p = 0.001) and serum creatine kinase (CK) (p = 0.019) but negatively correlated with serum CXCL12α (p = 0.023), a chemoattractant for muscle stem cells. In the case group, ASMI was negatively correlated with serum interleukin (IL)-7 (p = 0.024), a myokine expressed and secreted from skeletal muscle cells in vitro. Multivariate binary logistic regression analyses identified four risk factors for sarcopenia in our study: advanced age, malnutrition, low serum CK levels, and high serum CXCL12α levels. Moreover, a negative correlation was between ASMI and serum IL-16 in females only (p = 0.021). Women with sarcopenia exhibited significantly higher IL-16 (p = 0.025) serum levels than women in a control group. In contrast, males with sarcopenia had lower IL-16 (p = 0.013) levels than males in a control group. The further use of Fisher’s exact test identified obesity and high serum levels of IL-16 as significant risk factors for sarcopenia in females. In male older adults, however, malnutrition and low serum levels of IL-16 were the most significant risk factors for sarcopenia. Low CK and high CXCL12α levels serve as combinatorial serum markers of sarcopenia in older adults. And the differential sex-specific associations of IL-16 in older adults may contribute to the development of more precise regression models for future research and elucidate the role of IL-16 in the progression of sarcopenic obesity.
KW  - Aged (MeSH)
KW  - Female (MeSH)
KW  - Humans (MeSH)
KW  - Interleukin-16 (MeSH)
KW  - Male (MeSH)
KW  - Malnutrition (MeSH)
KW  - Muscles (MeSH)
KW  - Obesity: complications (MeSH)
KW  - Obesity: epidemiology (MeSH)
KW  - Sarcopenia: diagnosis (MeSH)
KW  - Sarcopenia: epidemiology (MeSH)
KW  - Interleukin-16 (NLM Chemicals)
KW  - IL-16 (Other)
KW  - MNA (Other)
KW  - older adults (Other)
KW  - sarcopenia (Other)
KW  - skeletal muscle (Other)
LB  - PUB:(DE-HGF)11
UR  - https://publications.rwth-aachen.de/record/986936
ER  -