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@PHDTHESIS{Chen:986936,
author = {Chen, Ze},
othercontributors = {Nourbakhsh, Mahtab and Pishnamaz, Miguel},
title = {{A}ssociations of serum {CXCL}12ɑ and {IL}-16 levels with
sarcopenia in older adults},
school = {Rheinisch-Westfälische Technische Hochschule Aachen},
type = {Dissertation},
address = {Aachen},
reportid = {RWTH-2024-05490},
pages = {12, 12 Seiten : Illustrationen, Diagramme},
year = {2024},
note = {Dissertation, Rheinisch-Westfälische Technische Hochschule
Aachen, 2024, Kumulative Dissertation},
abstract = {Sarcopenia, a condition characterized by gradual loss of
skeletal muscle mass and function, is a complex diagnosis;
the decisive criterion in this diagnosis is the measurement
of appendicular skeletal muscle index (ASMI). To identify
potential serum markers predictive of sarcopenia in older
adults, we evaluated correlations of 80 older adults between
ASMI, clinical data, and a total of 68 serum inflammation
markers in two consecutive analyses. Pearson’s correlation
analyses confirmed that ASMI was positively correlated with
nutritional status (p = 0.001) and serum creatine kinase
(CK) (p = 0.019) but negatively correlated with serum
CXCL12α (p = 0.023), a chemoattractant for muscle stem
cells. In the case group, ASMI was negatively correlated
with serum interleukin (IL)-7 (p = 0.024), a myokine
expressed and secreted from skeletal muscle cells in vitro.
Multivariate binary logistic regression analyses identified
four risk factors for sarcopenia in our study: advanced age,
malnutrition, low serum CK levels, and high serum CXCL12α
levels. Moreover, a negative correlation was between ASMI
and serum IL-16 in females only (p = 0.021). Women with
sarcopenia exhibited significantly higher IL-16 (p = 0.025)
serum levels than women in a control group. In contrast,
males with sarcopenia had lower IL-16 (p = 0.013) levels
than males in a control group. The further use of Fisher’s
exact test identified obesity and high serum levels of IL-16
as significant risk factors for sarcopenia in females. In
male older adults, however, malnutrition and low serum
levels of IL-16 were the most significant risk factors for
sarcopenia. Low CK and high CXCL12α levels serve as
combinatorial serum markers of sarcopenia in older adults.
And the differential sex-specific associations of IL-16 in
older adults may contribute to the development of more
precise regression models for future research and elucidate
the role of IL-16 in the progression of sarcopenic obesity.},
keywords = {Aged (MeSH) / Female (MeSH) / Humans (MeSH) /
Interleukin-16 (MeSH) / Male (MeSH) / Malnutrition (MeSH) /
Muscles (MeSH) / Obesity: complications (MeSH) / Obesity:
epidemiology (MeSH) / Sarcopenia: diagnosis (MeSH) /
Sarcopenia: epidemiology (MeSH) / Interleukin-16 (NLM
Chemicals) / IL-16 (Other) / MNA (Other) / older adults
(Other) / sarcopenia (Other) / skeletal muscle (Other)},
cin = {939410 ; 537200-2},
ddc = {610},
cid = {$I:(DE-82)939410_20191118$},
typ = {PUB:(DE-HGF)11},
url = {https://publications.rwth-aachen.de/record/986936},
}
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