gerKrebs, JaninaNeulen, JosephJahnen-Dechent, WilhelmDie Rolle des Fetuin-B im menschlichen Fertilisationsprozessinfo:eu-repo/classification/ddc/610The thesis “The role of Fetuin-B in the process of human fertilization”, written by Janina Krebs, examines the influence of Fetuin-B on the fertilization. The thesis investigates the association between Fetuin-B and fertilization rates (number of fertilized eggs) during an ART-Therapy (assisted reproductive technology). More precisely, the author analyses Fetuin-B’s ability to act as a biological prognostic marker. An additional research question of the thesis is, if Fetuin-B is influenced by characteristics such as age, body-mass-index (BMI), nicotine consumption, primary or secondary infertility. Therefore, Fetuin-B levels were measured multiple times from 101 patients that underwent ART-therapy for the first time. ELISA-technique was used for subsequent analysis. The main result is that Fetuin-B significantly increases during successful fertilization (fertilization rate >25%), whereas Fetuin-B does not increase during unsuccessful fertilization (fertilization rate <25%). A previous pilot study came to a same result, so these results confirm previous pilot studies and provides further evidence that Fetuin-B can act as a biological prognostic marker for fertilization rates. In addition, this study finds that Fetuin-B is not significantly influenced by individual characteristics. Drawing the conclusion, we observed a significantly increase of Fetuin-B during a successful fertilization (fertilization rate >25%) which underlines the essential importance of Fetuin-B during the fertilization. In future, it would be interesting to examine the promotor of gene regulation of Fetuin-B and to analyse if there are more association partners of Fetuin-B.Aachen : RWTH Aachen University 1 Online-Ressource : Illustrationen (2024). doi:10.18154/RWTH-2024-07681 = Dissertation, Rheinisch-Westfälische Technische Hochschule Aachen, 2024info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersionRWTH Aachen University2024info:eu-repo/semantics/openAccessDEhttps://publications.rwth-aachen.de/record/991096https://publications.rwth-aachen.de/search?p=id:%22RWTH-2024-07681%22StudentsStudent Financial Aid ProvidersTeachersResearchersinfo:eu-repo/semantics/altIdentifier/doi/10.18154/RWTH-2024-07681