h1

% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@PHDTHESIS{Doerenkamp:996426,
      author       = {Doerenkamp, Kerstin},
      othercontributors = {Grün, Sonja Annemarie and Kampa, Björn M.},
      title        = {“{M}ultisensory integration in superior colliculus and
                      primary visual cortex of awake behaving mice”},
      school       = {RWTH Aachen University},
      type         = {Dissertation},
      address      = {Aachen},
      publisher    = {RWTH Aachen University},
      reportid     = {RWTH-2024-10606},
      pages        = {1 Online-Ressource : Illustrationen},
      year         = {2024},
      note         = {Veröffentlicht auf dem Publikationsserver der RWTH Aachen
                      University; Dissertation, RWTH Aachen University, 2024},
      abstract     = {Having multiple senses is essential for survival, since
                      each sense is optimally suited to detect a different type of
                      stimulus. When combining the information gained from
                      multiple senses, more is revealed about the nature of an
                      object. The response to such a multisensory combination can
                      often even exceed the sum of its unimodal components. This
                      synergy of sensory responses has been shown repeatedly in
                      the multisensory area superior colliculus (SC). Previous
                      experiments have shown that combining multiple sensory
                      modalities can result in an increased performance in
                      behavioural tasks. This thesis aims to investigate the
                      neural origin for this increased performance. As a first
                      step to unravelling how multisensory stimuli are represented
                      and integrated in the brain, this study will focus on
                      sensory responses in the visual system. Three essential
                      areas of the mouse visual system are investigated: the
                      primary visual cortex (V1), the superficial part of the
                      superior colliculus (optic SC), and the deep part of the
                      superior colliculus (deep SC). While the V1 and the optic SC
                      are considered unisensory visual areas, the deep SC has been
                      acknowledged as a multisensory area. In the first part of
                      this study, multisensory responsiveness was compared between
                      different areas of the visual system. Mice were presented
                      with visual, tactile and auditory stimuli, while neuronal
                      activity was recorded in V1 and SC simultaneously using
                      high-density Neuropixels electrodes. The unisensory areas V1
                      and optic SC showed a surprisingly high occurrence of
                      multisensory integration that was almost on par with the
                      multisensory area deep SC. However, responses to nonvisual
                      stimuli alone were much rarer and often had longer latencies
                      in V1 and optic SC, indicating that crossmodal responses in
                      unisensory areas were not as meaningful as in a multisensory
                      area like the deep SC. In the second part, the effect of
                      training mice on a visuotactile discrimination task on the
                      multisensory responsiveness was investigated. Training
                      caused a general reduction of the response strength, coupled
                      with a decrease of the amount of responsive neurons in the
                      SC. Additionally, multisensory enhancement was strongly
                      reduced in trained mice, while multisensory depression was
                      not affected by training. These changes suggest that
                      training improves the accuracy of the stimulus detection by
                      decreasing sensory responses that are not necessary for
                      solving the behavioural task.},
      cin          = {163110 / 160000 / 080010},
      ddc          = {570},
      cid          = {$I:(DE-82)163110_20180110$ / $I:(DE-82)160000_20140620$ /
                      $I:(DE-82)080010_20140620$},
      pnm          = {GRK 2416 - GRK 2416: MultiSenses-MultiScales: Neue Ansätze
                      zur Aufklärung neuronaler multisensorischer Integration
                      (368482240)},
      pid          = {G:(GEPRIS)368482240},
      typ          = {PUB:(DE-HGF)11},
      doi          = {10.18154/RWTH-2024-10606},
      url          = {https://publications.rwth-aachen.de/record/996426},
}